Results 191 to 200 of about 544,097 (279)

Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Advanced Science, EarlyView.
This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, Alina Krumme, Maxime Le Marois, Angelika Fraas, Aslihan Inal, Mario Huerta, Vanessa Henriques, Eva Eiteneuer, Thomas Albrecht, Alphonse Charbel, Michael T. Dill, Carsten Sticht, Carolina De La Torre, Stefan Pusch, Arianeb Mehrabi, Kai Breuhahn, Junfang Ji, Peter Schirmacher, Benjamin Goeppert, Stephanie Roessler   +21 more
wiley   +1 more source

D-Serine Can Modify the Wall Teichoic Acid of MRSA via the <i>dlt</i> Pathway. [PDF]

Int J Mol Sci
Wang L, Xie J, Wang Q, Wang P, Hu X, Nie T, Hou L, Yang X, Wang X, You X, Li C.   +10 more
europepmc   +1 more source

The D-serine biosynthetic enzyme serine racemase is expressed by reactive astrocytes in the amygdala of human and a mouse model of Alzheimer's disease. [PDF]

Neurosci Lett, 2023
Folorunso OO, Harvey TL, Brown SE, Chelini G, Berretta S, Balu DT.   +5 more
europepmc   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Variations of blood D-serine and D-aspartate homeostasis track psychosis stages. [PDF]

Schizophrenia (Heidelb)
Rampino A, Garofalo M, Nuzzo T, Favia M, Saltarelli S, Masellis R, Asselti MG, Pennacchio TC, Bruzzese D, Errico F, Vidali M, Bertolino A, Usiello A.   +12 more
europepmc   +1 more source

Inhibition of glial D-serine release rescues synaptic damage after brain injury. [PDF]

Glia, 2022
Tapanes SA, Arizanovska D, Díaz MM, Folorunso OO, Harvey T, Brown SE, Radzishevsky I, Close LN, Jagid JR, Graciolli Cordeiro J, Wolosker H, Balu DT, Liebl DJ.   +12 more
europepmc   +1 more source

Fabrication and use of D-serine biosensors for characterising D-serine signalling in rat brain [PDF]

D-serine is a co-agonist at NMDA receptors in the brain but the study of this amino\ud acid is restricted by current techniques. I have designed highly sensitive D-serine\ud biosensors that permit accurate real-time recordings of D-serine in the brain in a\ud selective manner.
openaire  

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

Enantioselective electrochemical detection of a L-and D-serine at polyvinylpyrrolidone-modified platinum electrode. [PDF]

Bioanalysis
Amayreh M, Hourani MK.
europepmc   +1 more source

d-Serine Mediates Cellular Proliferation for Kidney Remodeling. [PDF]

Kidney360, 2021
Hesaka A, Tsukamoto Y, Nada S, Kawamura M, Ichimaru N, Sakai S, Nakane M, Mita M, Okuzaki D, Okuzaki D, Okada M, Isaka Y, Kimura T, Kimura T.   +13 more
europepmc   +1 more source