Results 171 to 180 of about 14,981,197 (293)

D-serine: A Multitalented Neuromodulator in Brain Function, Systemic Homeostasis, and Disease. [PDF]

Cell Mol Neurobiol
Wang J, Guo Y, Han W, Zhang H, Jiang P.
europepmc   +1 more source

D-serine availability modulates prefrontal cortex inhibitory interneuron development and circuit maturation. [PDF]

Sci Rep, 2023
Folorunso OO, Brown SE, Baruah J, Harvey TL, Jami SA, Radzishevsky I, Wolosker H, McNally JM, Gray JA, Vasudevan A, Balu DT.   +10 more
europepmc   +1 more source

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source

D-serine reconstitutes synaptic and intrinsic inhibitory control of pyramidal neurons in a neurodevelopmental mouse model for schizophrenia. [PDF]

Nat Commun, 2023
Zhang XQ, Xu L, Zhu XY, Tang ZH, Dong YB, Yu ZP, Shang Q, Wang ZC, Shen HW.   +8 more
europepmc   +1 more source

The Mitogen‐Activated Protein Kinase GhNTF3 Modulates the Arbuscular Mycorrhizal Symbiosis‐Immunity Trade‐Off in Cotton by Regulating Salicylic Acid Biosynthesis

Advanced Science, EarlyView.
AM symbiosis induces GhWAK13 to promote fungal colonization. GhNTF3 negatively regulates symbiosis by promoting SA biosynthesis. GhWAK13 sequesters GhNTF3 at the membrane, limiting its nuclear translocation and relieving SA‐mediated suppression. Under Verticillium stress, GhNTF3 enters the nucleus and interacts with GhJAZ6 to activate SA signaling ...
Shuangjie Jia, Jingshang Wen, Jihang Li, Meina Feng, Yiming He, Ruojun Liu, Qian Liu, Junli Zhang, Kai Cheng, Xiangyu Zhang, Xiao Zhang   +10 more
wiley   +1 more source

D-serine and D-alanine supplementation protects against chronic kidney disease. [PDF]

Sci Rep
Nakade Y, Iwata Y, Toyama T, Kobayashi T, Mita M, Yamamura Y, Oshima M, Tokumaru T, Kitajima S, Shimizu M, Sakai N, Wada T.   +11 more
europepmc   +1 more source

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

D-serine in health and disease

, 2010
Amino acids are among the most important molecules for living beings, since they are used to build peptides and proteins. Depending on their spatial positioning, amino acids can occur as D- or L-amino acids. This determines the function of peptides and proteins in the human body. It was long thought that only L-amino acids occurred in nature.
Fuchs, S.A., Child Health, Circulatory Health, Infection & Immunity, Metabole ziekten, Berger, R., Kimpen, JLL, de Koning,T.J., Klomp,L.W.J.   +8 more
openaire   +1 more source

Involvement of trimethylamine N-oxide in major depressive disorder via astrocytic d-Serine dysregulation. [PDF]

Neurotherapeutics
Lin L, Li L, Ren S, Liu L, Liu Y, Zhang W, Gao Z, Ni X, Li H, Duan X, Tao S, Zhao T, Hai X.   +12 more
europepmc   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source