Results 51 to 60 of about 14,111 (239)

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

A maize polygalacturonase functions as a suppressor of programmed cell death in plants

BMC Plant Biology, 2019
Background The hypersensitive defense response (HR) in plants is a fast, localized necrotic response around the point of pathogen ingress. HR is usually triggered by a pathogen recognition event mediated by a nucleotide-binding site, leucine-rich repeat (
Yijian He, Shailesh Karre, Gurmukh S. Johal, Shawn A. Christensen, Peter Balint-Kurti   +4 more
doaj   +1 more source

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

Mutations that abrogated Rp1-D21-induced HR identified in an EMS mutagenesis screen in maize. [PDF]

, 2015
a *indicates stop codon.b +: strong self-association;+/-: weak self-association.Mutations that abrogated Rp1-D21-induced HR identified in an EMS mutagenesis screen in maize.
Guri Johal (696264), Farid EI-Kasmi (696263), Jeffery L. Dangl (24084), Peter J. Balint-Kurti (623037), Jiabing Ji (364920), Guan-Feng Wang (623027)   +5 more
core   +1 more source

MPTP impairs dopamine D1 receptor-mediated survival of newborn neurons in ventral hippocampus to cause depressive-like behaviors in adult mice

Frontiers in Molecular Neuroscience, 2016
Parkinson’s disease is characterized by motor symptoms with depression. We evaluated the influence of dopaminergic depletion on hippocampal neurogenesis process to explore mechanisms of depression production.
Tingting Zhang, Tingting Zhang, Juan Hong, Juan Hong, Tingting Di, Ling Chen, Ling Chen   +6 more
doaj   +1 more source

The BTB/POZ‐MATH Protein ZmBPM1 Interacts With Autophagy‐related Protein ZmATG6 and Modulates the NLR Protein Rp1‐D21‐Mediated Defense Response in Maize

Advanced Science, EarlyView.
The maize BTB/POZ‐MATH (BPM) protein ZmBPM1 interacts with autophagy‐related protein ZmATG6 to relocate the NLR protein Rp1‐D21 from the nucleo‐cytoplasmic compartment into autophagosome‐like puncta, leading to autophagy‐mediated turnover and suppressing the hypersensitive response.
Chang‐Xiao Tang, Tong‐Tong Liu, Qi‐Dong Ge, Xiao‐Ying Liu, Wanxiao Wang, Yang Sun, Yanfei Liu, Faqiang Li, Guan‐Feng Wang   +8 more
wiley   +1 more source

Increased expression of Mφ genes exclusively in prepartum D21 rat cervix (p<0.01; n = 3/group). [PDF]

, 2015
Function designations in rat derived from DAVID (http://david.abcc.ncifcrf.gov), Biolayout Express3D cluster analyses, and IPA (ECM = extracellular matrix, INFL = inflammation, SIG = Signaling).Increased expression of Mφ genes exclusively in prepartum ...
Ravi Goyal (499376), Abigail E. Dobyns (495221), Lauren Grisham Carpenter (712760), Steven M. Yellon (495220), Lawrence D. Longo (499380), Tom C. Freeman (18637)   +5 more
core   +1 more source

Effect of Cyclic Heat Exposure on the Growth Performance and Metabolism of Broilers Fed Palm Kernel Meal

Animal Research and One Health, EarlyView.
The aim of our study is to evaluate the interaction between HS and the incorporation of PKM in broiler chicken diets, as well as its effect on growth performance and metabolism. Based on the results obtained, PKM supplementation failed to mitigate the adverse effects of heat stress in broiler chickens. ABSTRACT The aim of this study was to evaluate the
Ahmed Mijiyawa, Elham Ghashghaei, Okasha Hamada, Huimin Wang, Lijing Sun, Yendouhamtchié Nadiedjoa, Dan Wang, Zhengkai Yue, Clarice Maa Maa Temhoul, Maxwell Ansong Okai, Muhammad Faisal Riaz, Felix Kwame Amevor, Wéré Pitala, Hai Lin   +13 more
wiley   +1 more source

Immunofluorescent staining of ZO1 in the ileum and colon of CPF-exposed (1 mg/kg/day, CPF1) rats and control (CPF0) rats at weaning (D21) and as young adults (D60). Magnification: x 630. [PDF]

, 2014
D21: CPF0 n = 5, CPF1 n = 5; D60: CPF0 n = 5, CPF1 n = 5. ZO-1 detection at D21 and D60 in CPF0rats (panels A and C, respectively) and in CPF1rats (panels, B and D respectively).
Claire Joly Condette (597562), Véronique Bach (429041), Hafida Khorsi-Cauet (597563), Jérôme Gay-Quéheillard (597567), Luciane Zabijak (597565), Patrice Morlière (597564), Julie Reygner (597566)   +6 more
core   +1 more source

Flap perfusion of superficial split flap design for guided bone regeneration: A case report with ultrasonography

Clinical Advances in Periodontics, EarlyView.
Abstract Background Effective flap management is crucial for successful bone regeneration procedures. Traditional flap release has been performed by the deep split design; recently, the superficial split design revives for its proposed anatomical and biomechanical advantages.
Oscar Durán‐Garnica, Karen Villarreal‐Arizpe, Amanda Rodríguez, Oliver Kripfgans, Hsun‐Liang Chan   +4 more
wiley   +1 more source