Results 121 to 130 of about 20,750 (203)

BRAF/MEK inhibitors use for pediatric gliomas; real world experience from a resource-limited country

Frontiers in Oncology
IntroductionMost pediatric low-grade-gliomas (LGG) and some high-grade-gliomas (HGG) have alterations in the RAS/MAPK pathway. Promising high tumor response rates were achieved using BRAF/MEK inhibitors, however data on their use in low-middle-income ...
Dima Abu Laban, Abeer Alsharif, Maysa Al-Hussaini, Mouness Obeidat, Bayan Maraqa, Qasem Alzoubi, Awni Musharbash, Saad Jaddoua, Raed Ramlawi, Kawther Khaleifeh, Ahmad Kh. Ibrahimi, Nasim Sarhan, Eric Bouffet, Nisreen Amayiri   +13 more
doaj   +1 more source

Kinase inhibitors in thyroid cancers

Endocrine Oncology
Objective: The treatment landscape for thyroid cancers has changed rapidly with the availability of kinase inhibitors against VEGFR, BRAF, MEK, NTRK, and RET.
Vineeth Sukrithan, Prachi Jain, Manisha H Shah, Bhavana Konda   +3 more
doaj   +1 more source

Heart Failure With Reduced Ejection Fraction in a Patient With Erdheim-Chester Disease on Dabrafenib

JACC: Case Reports
A 54-year-old woman with a diagnosis of Erdheim-Chester disease under therapy with dabrafenib presents with clinical signs of heart failure. After discontinuing the offending medication and initiating guideline-directed medical therapy for heart failure ...
Santiago Saenz-Ancira, MD, Javier Higuera-Ornelas, MD, Breno Bernades-Souza, MD, Ryan Severdija, MD, Maria Jose Santa Ana-Bayona, MS, Maria Silvana Salazar, MD, Moises A. Vazquez, MD, Jose Antonio Luna-Alvarez, MD   +7 more
doaj   +1 more source

Conjunctival Melanoma: Update on Genetics, Epigenetics and Targeted Molecular and Immune-Based Therapies

Clinical Ophthalmology, 2020
Anastasia Gkiala,1 Sotiria Palioura2 1National and Kapodistrian University of Athens School of Medicine, Athens, Greece; 2Athens Vision Eye Institute, Athens, GreeceCorrespondence: Sotiria PaliouraAthens Vision Eye Institute, 328-330 Syngrou Ave ...
Gkiala A, Palioura S
doaj  

Distant intracranial failure in melanoma brain metastases treated with stereotactic radiosurgery in the era of immunotherapy and targeted agents [PDF]

, 2017
Abraham, Christopher, Acharya, Sahaja, Chicoine, Michael, Dowling, Joshua, Dunn, Gavin, Huang, Jiayi, Keller, Jesse, Leuthardt, Eric, Mahmood, Mustafaa, Mullen, Daniel, Perkins, Stephanie M, Rich, Keith, Robinson, Clifford G, Tsien, Christina I, Yang, Deshan   +14 more
core   +2 more sources

An ex vivo functional biomarker of treatment response in pediatric low-grade glioma. [PDF]

PLoS One
Artz NM, Mann B, Ebbs A, Darawsheh R, Dasari R, Adefolaju A, Bell N, Trembath D, Higgins D, Elton S, Baldwin A, Hingtgen S, Kram DE, Satterlee AB.   +13 more
europepmc   +1 more source

Dabrafenib [PDF]

, 2020
openaire   +1 more source

Role of the ETV5/p38 Signaling Axis in Aggressive Thyroid Cancer Cells. [PDF]

Mol Cancer Ther
Houl JH, Bagheri-Yarmand R, Kunnimalaiyaan M, Miranda Mendez P, Kidd JL, Dadbin A, Ruiz-Jurado A, Parekh PA, Henderson YC, Chari NS, Thennavan A, Powell RT, Stephan CC, Zhao X, Maniakas A, Nurieva R, Busaidy NL, Cabanillas ME, Dadu R, Zafereo M, Wang JR, Lai SY, Hofmann MC.   +22 more
europepmc   +1 more source

Clinical efficacy and cardiac toxicity associated with first-line dabrafenib plus trametinib in advanced BRAF V600_K601delinsE-mutated lung adenocarcinoma: a case report and literature review. [PDF]

Discov Oncol
Yang L, Liu X, Zhu X, Cao B, Gu Y, Liu W.   +5 more
europepmc   +1 more source

Dual targeting of BRAF^V600E and ferroptosis results in synergistic anticancer activity via iron overload and enhanced oxidative stress. [PDF]

J Exp Clin Cancer Res
Hu J, Ghosh C, Khaket TP, Yang Z, Tabdili Y, Alamaw ED, Boufraqech M, Dixon SJ, Kebebew E.   +8 more
europepmc   +1 more source