Results 81 to 90 of about 20,750 (203)

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Benign Keratoses With Inverted Follicular Keratosis‐Like Features in a Patient Receiving Ripretinib: A Case Report

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Inverted follicular keratosis (IFK) is a rare benign neoplasm of the follicular infundibulum and typically presents as a solitary, nonpigmented verrucous papule on the head and neck of older males and can mimic viral warts, basal cell carcinoma (BCC), or squamous cell carcinoma (SCC). We report a case of multiple benign keratoses with IFK‐like
Elsayed Ibrahim, Saira George, Peter N. Kundert, Benjamin H. Perkins, Jonathan L. Curry, Phyu P. Aung   +5 more
wiley   +1 more source

Molecular testing for BRAF mutations to inform melanoma treatment decisions: a move toward precision medicine [PDF]

, 2018
Approximately one-half of advanced (unresectable or metastatic) melanomas harbor a mutation in the BRAF gene, with V600E being the most common mutation.
Cheng, Liang, Lopez-Beltran, Antonio, MacLennan, Gregory T., Massari, Francesco, Montironi, Rodolfo   +4 more
core   +1 more source

From mechanism to phenotype: What fits in a basket trial

Epilepsia, EarlyView.
Kette D. Valente
wiley   +1 more source

Real‐world management of adjuvant systemic melanoma therapy: Multi‐center survey of 51 DeCOG skin cancer centers

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Adjuvant immune checkpoint inhibitors (ICI) and targeted therapy (TT) have revolutionized treatment management for patients with melanoma. However, the current German S3 guideline does not differentiate between patients with and without adjuvant therapy in its recommendations for imaging intervals and follow‐up monitoring, leading to
Markus Reitmajer, Elisabeth Livingstone, Lucie Heinzerling, Kai‐Martin Thoms, Frank Meiss, Markus V. Heppt, Anja Gesierich, Konstantin Drexler, Friedegund Meier, Max Schlaak, Andrea Forschner, Lisa Zimmer   +11 more
wiley   +1 more source

Durable Complete Response of a Recurrent Mesencephalic Glioblastoma Treated with Trametinib and Low-Dose Dabrafenib in a Patient with Neurofibromatosis Type 1

Case Reports in Oncology, 2020
Patients with neurofibromatosis type 1 (NF1) have an increased lifetime risk for the development of nervous system tumors, including high-grade gliomas (glioblastoma).
Gil Awada, Daphne Serruys, Julia Katharina Schwarze, Lien Van De Voorde, Johnny Duerinck, Bart Neyns   +5 more
doaj   +1 more source

Emerging targeted therapies for melanoma treatment (Review) [PDF]

, 2014
Cutaneous melanoma is an aggressive cancer with a poor prognosis for patients with advanced disease. The identification of several key molecular pathways implicated in the pathogenesis of melanoma has led to the development of novel therapies for this ...
Agarwala, Akinleye, ANGELA RUSSO, ANTONIO BIONDI, Antony, Aplin, Ascierto, Ascierto, Ascierto, Awada, BARTOLOMEA FICILI, Bataille, Bollag, Brana, Britten, Byron, Candido, Catalanotti, Chakraborty, Chang, Chapman, Chen, Chmielowski, CLAUDIO GUARNERI, Comin-Anduix, Corcoran, Curti, Davar, Davies, DEMETRIOS A. SPANDIDOS, Di Giacomo, Donia, Eisen, Eisen, Emery, Falchook, Falchook, Fellner, Feng, Flaherty, Flaherty, FRANCA MARIA PEZZINO, Garnett, Gilmartin, Gray-Schopfer, Greger, Hafsi, Hauschild, Hodi, Hodis, Hwu, Ikenoue, Infante, Isakoff, JAMES A. McCUBREY, Jang, Janku, Jessen, Johnson, Joseph, Karasarides, Kim, Kirkwood, Klinac, Levings, Libra, Ligresti, Lipkin, Lipson, Liu, Lo, Long, Mansh, Markman, MASSIMO LIBRA, McCubrey, McCubrey, McCubrey, Meier, Melero, Melero, Mendoza, Mijatovic, Oberholzer, Ogita, Pecuchet, Robert, Robert, Russo, SALVATORE TRAVALI, SAVERIO CANDIDO, Shahabi, Shao, Sondak, Sosman, Stahl, Strumberg, Strumberg, Su, Thomas, Thomas, Thompson, Tjin, Topalian, Trefzer, Trunzer, Tsai, Venesio, Villanueva, Viola, Vredeveld, Wargo, Weber, Wilhelm, Wilhelm, Wilmott, Wolchok, Yamaguchi, Zhao, Zhao   +119 more
core   +2 more sources

Neoadjuvant therapy in skin cancer: current evidence and future perspectives

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary The development of immune checkpoint inhibitors and targeted therapies has fundamentally changed the treatment of cutaneous malignancies, especially in squamous cell carcinoma, melanoma, and Merkel cell carcinoma. The latest neoadjuvant approaches have shown promising results in locally advanced stages.
Lea Daniello, Johannes Kleemann, Bastian Schilling   +2 more
wiley   +1 more source

Dabrafenib plus Trametinib: A breakthrough in pediatric low‐grade glioma therapy

Health Science Reports
Background and Aims Pediatric‐type low‐grade gliomas (pLGGs) are the most common solid tumors in children, with v‐raf murine sarcoma viral oncogene homolog B (BRAF) mutations playing a significant role in their development.
Marrium Sultan Dar, Nayab Shahid, Arisha Waqas, Yumna Arif Baig, Aimen Waqar Khan   +4 more
doaj   +1 more source

Future perspectives in melanoma research: meeting report from the “Melanoma Bridge”, Napoli, December 5th-8th 2013 [PDF]

, 2014
The fourth “Melanoma Bridge Meeting” took place in Naples, December 5 to 8th, 2013. The four topics discussed at this meeting were: Diagnosis and New Procedures, Molecular Advances and Combination Therapies, News in Immunotherapy, and Tumor ...
Anderson, Ana Carrizosa, Ascierto, Paolo A, Bifulco, Carlo, Ciliberto, Gennaro, Cochran, Alistair, Eggermont, Alexander M, Faries, Mark, Ferrone, Soldano, Gajewski, Thomas F, Garbe, Claus, Gershenwald, Jeffrey E, Grimaldi, Antonio M, Halaban, Ruth, Hodi, F Stephen, Kefford, Richard, Kirkwood, John M, Larkin, James, Leachman, Sancy, Maio, Michele, Marais, Richard, Marincola, Francesco M, Masucci, Giuseppe, Melero, Ignacio, Mozzillo, Nicola, Palmieri, Giuseppe, Puzanov, Igor, Ribas, Antoni, Saenger, Yvonne, Schilling, Bastian, Seliger, Barbara, Stroncek, David, Sullivan, Ryan, Testori, Alessandro, Thurin, Magdalena, Wang, Ena   +34 more
core   +6 more sources