Results 91 to 100 of about 17,734 (168)

Impact of 06-methylguanine-DNA methyltransferase (MGMT) promoter methylation and MGMT expression on dacarbazine resistance of Hodgkin's lymphoma cells

, 2014
We analyzed the methylation status of the 06-methylguanine-DNAmethyltransferase (MGMT) promoter and mRNA expression in HL cells and assessed the response of these cells to dacarbazine.
Kewitz, Stefanie, Kramm, Christof M., Stiefel, Martina, Staege, Martin S.   +3 more
core   +1 more source

Tumor-Targeted nitric Oxide-Loaded nanoliposomes for modulating the tumor microenvironment and enhancing the efficacy of dacarbazine in melanoma

Materials & Design
Background: Malignant melanoma is a highly malignant tumor that results from the malignant transformation of melanocytes. It is mainly accompanied by changes in the immune microenvironment and severe intra-tumor vascular abnormalities, which ...
Yueling Yang, Jiaxuan Gan, Ziyao Xie, Xinyu Su, Yirong Wu, Lanqun Qin, Jiayu Wang, Mengke Zhao, Zhengyun Zou   +8 more
doaj   +1 more source

Combination chemotherapy with 5-fluorouracil and dacarbazine in advanced medullary thyroid cancer, a possible alternative?

, 2017
Combination chemotherapy with 5-fluorouracil and dacarbazine in advanced medullary thyroid cancer, a possible ...
Françoise Descotes (366487), Françoise Borson-Chazot (2743144), Lucien Marchand (2743147), Cécile Nozières (2743141), Myriam Decaussin-Petrucci (2743129), Claire Bournaud (2743135), Thomas Walter (221641), Marie-Odile Joly (2743138), Véronique Lapras (2743132)   +8 more
core   +1 more source

Dacarbazine mediate antimelanoma effects via NK cells.

, 2013
International audienceMelanoma is a highly chemoresistant and metastatic tumor that, in the absence of BRAF mutations, is generally treated with the alkylating agent dacarbazine (DTIC).
Hervieu, Alice, Mignot, Gregoire, Ghiringhelli, François   +2 more
core   +1 more source

Doxorubicin, bleomycin, vinblastine, and dacarbazine for Hodgkin lymphoma: Real-world experience from a Los Angeles County hospital

SAGE Open Medicine
Objective: While there are significant ongoing advancements in the management of Hodgkin lymphoma, doxorubicin + bleomycin + vinblastine + dacarbazine remains a preferred option for early stage Hodgkin lymphoma and is a frequently used first-line ...
Eugene Chao, Joseph P. Marshalek, David Yashar, Sarah Tomassetti   +3 more
doaj   +1 more source

Lower doses of dacarbazine (modified BEACODD) as a safer strategy with equal effectiveness in an intensive treatment protocol of Hodgkin's lymphoma: a preliminary retrospective analysis of a single public center in Brazil

Hematology, Transfusion and Cell Therapy
The German Hodgkin Study Group developed the escalated BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) protocol as a treatment strategy for advanced-stage Hodgkin's lymphoma.
Larissa Hilario Dulley, Arthur Gomes Oliveira Braga, Guilherme Garcia Rodrigues, Sergio Costa Fortier, Carlos Sérgio Chiattone, Talita Maira Bueno da Silveira   +5 more
doaj   +1 more source

Electrochemical sensor based on multi-walled carbon nanotubes and two-dimensional zeolitic imidazolate framework nanosheets: Application in determining dacarbazine

ADMET and DMPK
Background and Purpose: Cancer is a serious public health concern, hence the determination of dacarbazine as a significant chemotherapeutic agent is very important.
Somayeh Tajik, Hadi Beitollahi, Fariba Garkani Nejad, Zahra Dourandish, Samuel Adeloju   +4 more
doaj   +1 more source

Determination of N7-methylguanine in DNA of white blood cells from cancer patients treated with dacarbazine

, 1992
An ELISA method was used to determine N7-methylguanine (N7-MeGua) adducts in DNA of white blood cells from cancer patients treated with the methylating antitumor drug dacarbazine by i.v. administration.
Ende, A.M.C. van den, Baan, R.A., Delft, J.H.M. van, Ouwerkerk, J., Keizer, H.J.   +4 more
core  

Infrared spectra of primary melanomas can predict response to chemotherapy: The example of dacarbazine

, 2016
Metastatic melanomas are highly aggressive and median survival is 6-9. months for stage IV patients in the absence of treatment with anti-tumor activity.
Goormaghtigh, Erik, N. Wald, E. Goormaghtigh, Martin, L, Le Corre, Yannick, L. Martin, Wald, Noémie, Y. Le Corre, Mathieu, Véronique, V. Mathieu   +9 more
core   +1 more source

Insulin induces drug resistance in melanoma through activation of the PI3K/Akt pathway

Drug Design, Development and Therapy, 2014
Mengna Chi,1 Yan Ye,1 Xu Dong Zhang,1 Jiezhong Chen2,3 1School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW, Australia; 2School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia; 3Faculty of ...
Chi M, Ye Y, Zhang XD, Chen J
doaj