Results 61 to 70 of about 141 (84)

Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors. [PDF]

Nat Commun
Cao J, Belousoff MJ, Johnson RM, Keov P, Mariam Z, Deganutti G, Christopoulos G, Hick CA, Reedtz-Runge S, Glendorf T, Ballarín-González B, Raun K, Bayly-Jones C, Wootten D, Sexton PM.   +14 more
europepmc   +1 more source

Thermogenesis in Adipose Tissue: Adrenergic and Non-Adrenergic Pathways. [PDF]

Cells
Hossain MA, Poojari A, Rabiee A.
europepmc   +1 more source

Impact of secretin receptor homo-dimerization on natural ligand binding. [PDF]

Nat Commun
Harikumar KG, Piper SJ, Christopoulos A, Wootten D, Sexton PM, Miller LJ.   +5 more
europepmc   +1 more source

Altered Intracellular Trafficking as a Mechanism for Prolonged Duration of G Protein-Coupled Receptor Activation. [PDF]

J Am Chem Soc
Kim TW, Gerrard EJ, Shin J, Gardella TJ, Wootten D, Sexton PM, Cary BP, Gellman SH.   +7 more
europepmc   +1 more source

SGLT2 Inhibitors and GLP-1 Receptor Agonists in Diabetic Kidney Disease: Evolving Evidence and Clinical Application. [PDF]

Diabetes Metab J
Bae JH.
europepmc   +1 more source

Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling. [PDF]

PLoS Biol
Harikumar KG, Zhao P, Cary BP, Xu X, Desai AJ, Dong M, Mobbs JI, Toufaily C, Furness SGB, Christopoulos A, Belousoff MJ, Wootten D, Sexton PM, Miller LJ.   +13 more
europepmc   +1 more source

What is the pipeline for future medications for obesity? [PDF]

Int J Obes (Lond)
Melson E, Ashraf U, Papamargaritis D, Davies MJ.   +3 more
europepmc   +1 more source

DACRA induces profound weight loss, satiety control, and increased mitochondrial respiratory capacity in adipose tissue

International Journal of Obesity
Dual amylin and calcitonin receptor agonists (DACRAs) are therapeutic candidates in the treatment of obesity with beneficial effects on weight loss superior to suppression of food intake. Hence, suggesting effects on energy expenditure by possibly targeting mitochondria in metabolically active tissue.Male rats with HFD-induced obesity received a DACRA,
Morten Karsdal, Anna Thorsø Larsen, Louise T Dalgaard   +2 more
exaly   +6 more sources

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KBP-088, a novel DACRA with prolonged receptor activation, is superior to davalintide in terms of efficacy on body weight

American Journal of Physiology - Endocrinology and Metabolism, 2016
This study aims to elucidate the mechanism behind the potent weight loss induced by dual amylin and calcitonin receptor agonists (DACRA) through comparison of the novel DACRA KBP-088 with the amylinomimetic davalintide with regard to in vitro receptor pharmacology and in vivo efficacy on food intake and body weight. KBP-088 and davalintide were tested
Morten Karsdal, Kim Henriksen, Kim Vietz Andreassen   +2 more
exaly   +3 more sources