Results 31 to 40 of about 5,407 (151)

Ligand‐Based Pharmacophore Modeling and Structure‐Based Virtual Screening for Identifying Potential Therapeutic Agents Targeting the SARS‐CoV‐2 Spike Protein‐ACE2 Receptor Interaction

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
A protocol guided by ligand‐based pharmacophore modeling and structure‐based virtual screening enabled the identification of 1H‐pyrazol‐5‐ol derivatives as novel inhibitors of the SARS‐CoV‐2 spike protein. The lead inhibitors, C‐3 and C‐4, could serve as templates for the design of potent antiviral agents targeting viral entry into host cells ...
Timoteo Delgado‐Maldonado, Gilberto Vargas‐Salas, Debasish Bandyopadhyay, Adriana Moreno‐Rodríguez, Eyra Ortiz‐Pérez, Gildardo Rivera   +5 more
wiley   +1 more source

Case report: Conservative treatment for fertility preservation in a woman with hemoperitoneum due to an invasive mole

Frontiers in Oncology, 2022
BackgroundInvasive moles are a subtype of gestational trophoblastic neoplasia (GTN) that usually develops after hydatidiform molar pregnancies. Uterine rupture in high-risk GTN is a rare and potentially catastrophic event.
Linjuan Xu, Min Feng, Jing Cai, Hongmei Li   +3 more
doaj   +1 more source

Interplay of RNA m6A/m1A/m5C/m7G/ψ Regulators Predicting the Prognosis of Pancreatic Cancer

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
In this study, we comprehensively analyze the 64 RNA modification regulators, including 24 m6A regulators, 13 m1A regulators, 12 m5C regulators, 9 m7G regulators, and 12 pseudouridine regulators in pancreatic cancer in TCGA, GTEx, and HPA databases. We investigate their RNA and protein expression, their association with patients' clinical significance,
Shiyin Chen, Jiawei Mao, Lin Xu, Linbei Lu, Yajuan Hao   +4 more
wiley   +1 more source

PVT1‐104aa derived from the 8q24 gene desert promotes colorectal cancer tumorigenesis

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
The schematic illustrates the dual oncogenic mechanism of circPVT1‐encoded PVT1‐104aa in CRC. First, MYC stabilization: (1) Direct binding to MYC; (2) phosphorylation of MYC at Ser62; (3) protection from GSK3β/FBW7‐mediated ubiquitination. Second, immunomodulation: (1) MYC‐dependent PD‐L1 upregulation; (2) enhanced therapeutic efficacy when combining ...
Maoguang Ma, Mingdian Wang, Yufei Yang, Dakui Luo, Weixing Dai, Yiwei Li, Sanjun Cai, Shaobo Mo, Qingguo Li, Xinxiang Li   +9 more
wiley   +1 more source

Uterine perforation associated with gestational trophoblastic disease and arteriovenous malformation: A case report

Case Reports in Women's Health
This case report outlines the clinical course of a young woman who presented as haemodynamically unstable due to uterine perforation. She had undergone suction dilation and curettage three weeks prior and received a diagnosis of complete molar pregnancy.
Lauren Fisher, Amin Bahabri, Anna Clare, Babak Shakeri   +3 more
doaj   +1 more source

Antibacterial Potential of Secondary Metabolites from Indonesian Marine Bacterial Symbionts

International Journal of Microbiology, 2020
Indonesian marine environments are known to house diverse organisms. However, the potential for bacteria from these environments as a source of antibacterial agents has not been widely studied.
Risa Nofiani, Alexandra J. Weisberg, Takeshi Tsunoda, Ruqiah Ganda Putri Panjaitan, Ridho Brilliantoro, Jeff H. Chang, Benjamin Philmus, Taifo Mahmud   +7 more
doaj   +1 more source

An Atypical Presentation, Diagnostic Challenges, and Treatment Response of a Malignant Small Round Cell Tumor in the Lumbo‐Inguinal Region of an Infant [PDF]

Clin Case Rep
ABSTRACT Malignant small round cell tumors are a heterogeneous group of aggressive neoplasms characterized by small, round cell morphology. The undifferentiated cells in these tumors exhibit a high nuclear‐cytoplasmic ratio, and definitive histologic diagnosis via light microscopy can be extremely challenging. Diagnostic accuracy significantly improves
Evele G, Francine K, George N, Bardin R.
europepmc   +2 more sources

Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley   +1 more source

Metastatic Choriocarcinoma Following Live Birth – A Rare Presentation

Bangabandhu Sheikh Mujib Medical University Journal, 2011
Choriocarcinoma is the most malignant tumor of gestational trophoblastic neoplasia. Post-partum choriocarcinoma is an infrequent event with poor prognosis.
Joya Sree Roy, Sadia Wasik, Afrina Begum, Md Murraf Hossen, Farhat Hossain   +4 more
doaj   +1 more source

Choriocarcinoma in tubal pregnancy: A case report

Clinical Case Reports, 2023
Key Clinical Message Choriocarcinoma of the fallopian tube is extremely rare and highly susceptible to early metastasis. Clinical manifestations of ectopic pregnancy and choriocarcinoma are the same, and all patients with ectopic pregnancy should be ...
Fateme Sadat Najib, Samaneh Bahrami, Zahra Shiravani, Seyed Mohammad Amin Alavi   +3 more
doaj   +1 more source