Results 21 to 30 of about 5,407 (151)
Eighteen patients with advanced seminoma (stages llc— III) were treated with: cytoxan 600mg/m2, vinblastine 4mg/m2, actinomycin D 1mg/m2, bleomycin 30mg, i.v.
Sergio D. Simon , Miguel Srougi
doaj +1 more source
Resistance to Single-agent Chemotherapy for Low-risk Gestational Trophoblastic Neoplasia
Background: Methotrexate (MTX) and actinomycin D (ActD) have been used as first-line chemotherapy agents in the treatment of low-risk gestational trophoblastic neoplasia (GTN).
Shahrzad Sheikhhasani +5 more
doaj
Nucleotide pools in mammalian cells change due to the influence of antitumor drugs, which may help in evaluating the drug effect and understanding the mechanism of drug action.
Fang Wang +4 more
doaj +1 more source
Biological Drivers of Wilms Tumor Prognosis and Treatment
Prior to the 1950s, survival from Wilms tumor (WT) was less than 10%. Today, a child diagnosed with WT has a greater than 90% chance of survival. These gains in survival rates from WT are attributed largely to improvements in multimodal therapy: Enhanced
Hannah M. Phelps +3 more
doaj +1 more source
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook +6 more
wiley +1 more source
Leptomeningeal spread of gestational trophoblastic neoplasia in a 19-year old woman
Gestational trophoblastic neoplasia (GTN) with brain metastasis is usually seen in patients with advanced disease. Ten percent of metastatic gestational trophoblastic disease involves the brain and spinal cord, most often manifesting as an intracerebral ...
Nnamdi I. Gwacham +3 more
doaj +1 more source
Chemotherapy induced juvenile dermatomyositis: a novel presentation- a case report
Background Idiopathic connective tissue disease juvenile dermatomyositis (JDM) is characterised by inflammatory myositis and distinctive skin abnormalities.
Keta Vagha +5 more
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ABSTRACT Although most malignant germ cell tumors (GCTs) are highly curable with cisplatin‐based therapy, options for patients with multiply relapsed/refractory disease remain limited. For this population, we report the first pediatric use of gemcitabine, docetaxel, melphalan, and carboplatin (GemDMC) as part of sequential cycles of high‐dose ...
Maria Frost +10 more
wiley +1 more source
Conservative multimodal management of a primitive neuroectodermal tumor of the thyroid
Primitive neuroectodermal tumors (PNET) represent 1% of sarcomas. Head and neck peripheral PNETs have an intermediate prognosis between abdominopelvic disease and extremities.
Juliette Haudebourg +9 more
doaj +1 more source
GT198 Is a Target of Oncology Drugs and Anticancer Herbs
Tumor angiogenesis is a hallmark of cancer. Therapeutic drug inhibitors targeting angiogenesis are clinically effective. We have previously identified GT198 (gene symbol PSMC3IP, also known as Hop2) as an oncoprotein that induces tumor angiogenesis in ...
Junfeng Pang +5 more
doaj +1 more source

