Inhibition of transcription by dactinomycin reveals a new characteristic of immunogenic cell stress
EMBO Molecular Medicine, 2020 Chemotherapy still constitutes the standard of care for the treatment of most neoplastic diseases. Certain chemotherapeutics from the oncological armamentarium are able to trigger pre‐mortem stress signals that lead to immunogenic cell death (ICD), thus ...
Wei Xie +2 more
exaly +2 more sources
GEFT inhibits the GSDM-mediated proptosis signalling pathway, promoting the progression and drug resistance of rhabdomyosarcoma [PDF]
Cell Death and DiseaseThe metastasis or recurrence of rhabdomyosarcoma (RMS) is the primary cause of tumour-related deaths. Patients with high-risk RMS have poor prognosis with a 5-year overall survival rate of 20–30%.
Fan Yang +11 more
doaj +2 more sources
A scientometric and comparative study of rhabdomyosarcoma research by pediatricians and stomatologists [PDF]
Journal of Dental SciencesBackground/purpose: Rhabdomyosarcoma (RMS) frequently affects pediatric patients and common occurs in the head and neck region. The purpose of this study was to compare the scientometric characteristics of RMS publications by pediatricians and ...
Wenke Chen +3 more
doaj +2 more sources
Progressive Metastatic Cutaneous <italic>TFCP2::FUS</italic> Fusion-Positive Rhabdomyosarcoma: A Case Report [PDF]
Case Reports in OncologyIntroduction: Rhabdomyosarcoma (RMS) rarely exhibits the TFCP2::FUS gene fusion and is even more rarely present as multiple cutaneous lesions.
Dustine Reich +4 more
doaj +2 more sources
Access to pediatric oncology medicine in Iran: a cross-sectional survey in Urmia [PDF]
BMC PediatricsBackground Cancer stands as a significant cause of mortality among children and adolescents, imposing a considerable burden on global healthcare. The World Health Organization (WHO) reports a stark imbalance in the accessibility of cancer medicines ...
Kiana Baghban +4 more
doaj +2 more sources
Drug Repurposing for Targeting ISL LIM Homeobox 2 in Treatment of Endometriosis: A Computational Study [PDF]
International Journal of Fertility and SterilityBackground: Endometriosis is a prevalent women's health disorder that lacks a definitive cure. Numerous studies have been conducted to identify the underlying causes of this disease and select the most effective pharmaceutical intervention.
Soodeh Mahdian +4 more
doaj +2 more sources
Potential secondary metabolite from Indonesian Actinobacteria (InaCC A758) against Mycobacterium tuberculosis [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): This study explored Indonesian Actinobacteria which were isolated from Curcuma zedoaria endophytic microbes and mangrove ecosystem for new antimycobacterial compounds.
Maya Rakhmawatie +5 more
doaj +1 more source
Clinical and Experimental Obstetrics & Gynecology, 2022 Background: With the increased frequency of diagnosis of interstitial pregnancy in the early first trimester, non-surgical management of unruptured interstitial pregnancy has become an important issue.
Akihiro Takeda +3 more
doaj +1 more source
Galanginin Protects AML-12 Cells Against Dactinomycin Induced Hepatotoxicity
Namık Kemal Tıp Dergisi, 2023 Aim:The purpose of this study was to evaluate the effects of galanginin (Gal) on dactinomycin induced hepatotoxicity in vitro.Materials and Methods:AML-12 cell line was divided into 4 groups as the control, Gal, dactinomycin, and Gal+dactinomycin groups.
Melek AKINCI +3 more
doaj +1 more source
Gynecologic Oncology Reports, 2023 Low-risk gestational trophoblastic neoplasia (GTN) is generally treated with single agent chemotherapy, including methotrexate (MTX) or dactinomycin.
Hector S. Porragas-Paseiro +3 more
doaj +1 more source