Results 81 to 90 of about 57,080 (289)
Advanced Science, EarlyView.We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang +13 more
wiley +1 more source
DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence.
PLoS Genetics, 2021 Quiescence, an actively-maintained reversible state of cell cycle arrest, is not well understood. PTEN is one of the most frequently lost tumor suppressors in human cancers and regulates quiescence of stem cells and cancer cells.
Amanda L Fry +5 more
doaj +1 more source
Advanced Science, EarlyView.A multilayer stretchable organic light‐emitting diode (SOLED) patch enables conformal, high‐fill‐factor phototherapeutic illumination through vertically decoupled electrodes and robust encapsulation. The textile‐based SOLED platform delivers stable skin‐contact red light for wearable phototherapy and 5‐aminolevulinic acid (ALA)‐mediated photodynamic ...
Young Hyun Son +5 more
wiley +1 more source
Frontiers in Microbiology, 2017 Haemonchus contortus (H. contortus) is one of the most important parasites of small ruminants, especially goats and sheep. The complex life cycle of this nematode is a main obstacle for the control and prevention of haemonchosis.
Yan Huang +8 more
doaj +1 more source
The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling. [PDF]
PLoS Biology, 2010 In Caenorhabditis elegans and Drosophila melanogaster, removing the germline precursor cells increases lifespan. In worms, and possibly also in flies, this lifespan extension requires the presence of somatic reproductive tissues.
Tracy M Yamawaki +6 more
doaj +1 more source
Porcine kidney xenotransplantation: From primate models to clinical reality
Animal Models and Experimental Medicine, EarlyView.In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo +3 more
wiley +1 more source
p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans.
PLoS Genetics, 2006 The PMK-1 p38 mitogen-activated protein kinase pathway and the DAF-2-DAF-16 insulin signaling pathway control Caenorhabditis elegans intestinal innate immunity.
Emily R Troemel +5 more
doaj +1 more source
, 2020 Additional file 3: Figure S2. Gene structures of R-Smad homologues from H. contortus (Hco-daf-8) and C. elegans (Cel-daf-8). Black boxes represent exons and the numbers above display the lengths of exons.
Jia-Nan Shan (8669883) +9 more
core +1 more source
Anatomical Sciences Education, EarlyView.Abstract While large language models (LLMs) have shown promise as learning tools for medical education, their reported accuracy on multiple‐choice questions (MCQs) varies widely across studies, necessitating synthesis. This meta‐analysis synthesizes LLM accuracy on text‐based MCQs from biomedical disciplines and USMLE Step 1‐level content and explores ...
Colleen M. Cheverko +26 more
wiley +1 more source
Research on Vehicle-bridge Coupling DAF of Straddle-type MTT Based on Elastic Net Regression
Chengshi guidao jiaotong yanjiuObjectiveThe straddle-type MTTS (monorail tour transit system) is classified as large-scale amusement facilities. Currently, there is relatively limited theoretical research on the vehicle-bridge coupling DAF(dynamic amplification factors) of MTTS, and ...
Changxing WU +3 more
doaj +1 more source