Results 131 to 140 of about 13,585 (158)

Promising targets of chrysin and daidzein in colorectal cancer: amphiregulin, CXCL1, and MMP-9.

European Journal of Pharmacology, 2020
Colorectal cancer is one of the primary causes of cancer-related mortality worldwide. The tumor microenvironment contains growth factors; inflammatory chemokines, matrix metalloproteinases, and pro-oxidants leading to cancer development and progression ...
A. Salama, R. Allam
semanticscholar   +1 more source

Inclusion Complexes of Daidzein with Cyclodextrin-Based Metal–Organic Framework-1 Enhance Its Solubility and Antioxidant Capacity

AAPS PharmSciTech, 2021
Daidzein, an aglycone-type isoflavone, is useful in the prevention of atherosclerotic cardiovascular diseases. However, the solubility of daidzein remains relatively low even with pharmaceutical interventions (e.g., γ-cyclodextrin inclusion complex).
Yutaka Inoue, M. Yoshida, Toshinari Ezawa, T. Tanikawa, F. Arce, G. L. See, Junki Tomita, Mitsuaki Suzuki, T. Oguchi   +8 more
semanticscholar   +1 more source

Daidzein ameliorates LPS-induced hepatocyte injury by inhibiting inflammation and oxidative stress.

European Journal of Pharmacology, 2020
Endotoxin-induced acute liver injury (ALI) is a severe disease associated with a poor prognosis. Therefore, it is urgent to discover new effective therapies to prevent ALI.
Zuying Yu, Liu Yang, Shan Deng, Minglu Liang   +3 more
semanticscholar   +1 more source

Isolation and identification of a human intestinal bacterium capable of daidzein conversion.

FEMS Microbiology Letters, 2021
Equol, which produced from daidzein (one of the principal isoflavones), is recognized to be the most resultful in stimulating an estrogenic and antioxidant response.
Yingyu Guo, Li-Chao Zhao, Xiang Fang, Qingping Zhong, Huijun Liang, Wenou Liang, Li Wang   +6 more
semanticscholar   +1 more source

Bioflavonoid Daidzein: Therapeutic Insights, Formulation Advances, and Future Directions

Drug Research
Bioflavonoids, are a diverse group of phytonutrients that are widely distributed in fruits, vegetables, grains, teas, and certain medicinal herbs. They are characterized by their antioxidant properties and play essential roles in plant biology, such as ...
Sana Ahmad, Farogh Ahsan, J. Ansari, T. Mahmood, Shahzadi Bano, Mo. Shahanawaz   +5 more
semanticscholar   +1 more source

Synergetic inhibition of daidzein and regular exercise on breast cancer in bearing-4T1 mice by regulating NK cells and apoptosis pathway.

Life Science, 2020
The aim of this study was to investigate the inhibition of daidzein or/and regular exercise on breast cancer and to reveal the potential biological mechanisms.
Bin Wang, Heshan Xu, Xiao-Ying Hu, Wenyu Ma, Jian Zhang, Yuanfeng Li, Min Yu, Yaru Zhang, Xue-Gang Li, Xiaoli Ye   +9 more
semanticscholar   +1 more source

Daidzein ameliorates diabetic retinopathy in experimental animals.

Life Science, 2020
AIM The present study was designed to check the effect of daidzein in the management of diabetic retinopathy. MAIN METHODS Streptozotocin at dose 55 mg/kg was used for inducing diabetes in rats. After 28 days of diabetic induction, animals were treated
A. Laddha, Yogesh A. Kulkarni
semanticscholar   +1 more source

In-vivo and in-silico toxicity studies of daidzein: an isoflavone from soy

Drug and chemical toxicology (New York, N.Y. 1978), 2020
Daidzein is a naturally occurring compound belonging to the class isoflavones and found in soya beans and other legumes. Acute oral toxicity was performed as per OECD guideline (TG 423) with slight modifications.
A. Laddha, S. Murugesan, Yogesh A. Kulkarni   +2 more
semanticscholar   +1 more source

Formulation and in vitro evaluation of topical nanoemulsion and nanoemulsion-based gels containing daidzein

Journal of Drug Delivery Science and Technology, 2019
Daidzein (DZ) has antioxidant, anti-inflammatory activities and also inhibits the growth of the cancer cells. The aim of this study is to formulate nanoemulsions (NEs) and nanoemulsion-based gels (NEGs) containing DZ, in order to evaluate their cytotoxic
A. U. Uğur Kaplan, M. Çetin, Dilara Orgul, A. Taghizadehghalehjoughi, A. Hacımuftuoglu, S. Hekimoglu   +5 more
semanticscholar   +1 more source

Protective effect of daidzein against streptozotocin‐induced Alzheimer's disease via improving cognitive dysfunction and oxidative stress in rat model

Journal of biochemical and molecular toxicology, 2019
Oxidative stress is performing an essential role in developing Alzheimer's disease (AD), and age‐related disorder and other neurodegenerative diseases.
Jie Wei, Fenggang Yang, Chuan-Bao Gong, Xingyuan Shi, Guangliang Wang   +4 more
semanticscholar   +1 more source