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Daidzein normalized gentamicin-induced nephrotoxicity and associated pro-inflammatory cytokines in MDCK and zebrafish: Possible mechanism of nephroprotection.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2022
This study investigates the therapeutic activity of daidzein, an isoflavone that occurs naturally in plants and herbs, against gentamicin-induced nephrotoxicity in Madin-Darby canine kidney (MDCK) cells in-vitro and zebrafish model in-vivo.
Ajay Guru   +8 more
semanticscholar   +1 more source

Daidzein suppresses TGF-β1-induced cardiac fibroblast activation via the TGF-β1/SMAD2/3 signaling pathway.

European Journal of Pharmacology, 2022
Myocardial fibrosis is a concomitant bioprocess associated with many cardiovascular diseases (CVDs). Daidzein is an isoflavone that has been used for the treatment of CVDs. This study aimed to reveal its role in myocardial fibrosis.
Jiangcheng Shu   +6 more
semanticscholar   +1 more source

Daidzein ameliorates doxorubicin-induced cardiac injury by inhibiting autophagy and apoptosis in rats.

Food & Function, 2022
Backgrounds: Doxorubicin (Dox) is a classical antitumor antibiotic widely restricted for use due to its cardiotoxicity. Daidzein (Daid) is a soy isoflavone that enhances antioxidant enzyme systems and inhibits apoptosis to prevent cardiovascular diseases.
Jin-Xia Wu   +10 more
semanticscholar   +1 more source

Daidzein mitigates myocardial injury in streptozotocin-induced diabetes in rats.

Life Science, 2021
AIM Present study focuses on the effect of daidzein in an experimental model of diabetic cardiomyopathy in rats. MATERIALS AND METHODS Diabetes was induced in male Sprague Dawley rats by a single intraperitoneal injection of STZ at dose 55 mg/kg ...
A. Laddha, Yogesh A. Kulkarni
semanticscholar   +1 more source

Soy protein adhesive with bio-based epoxidized daidzein for high strength and mildew resistance

, 2020
Soy protein based adhesives showed great potential for replacing petroleum derived formaldehyde adhesives in the commercial wood industry. However, soy protein adhesives have several problematic limitations, particularly with respect to low water and ...
Chaojie Xu   +6 more
semanticscholar   +1 more source

Daidzein and Genistein: Natural Phytoestrogens with Potential Applications in Hormone Replacement Therapy

International Journal of Molecular Sciences
Menopause is characterized by a decline in estrogen levels, leading to symptoms such as vasomotor instability, osteoporosis, and increased cardiovascular and cognitive risk.
Aekkhaluck Intharuksa   +8 more
semanticscholar   +1 more source

Stability and encapsulation properties of daidzein in zein/carrageenan/sodium alginate nanoparticles with ultrasound treatment.

International Journal of Biological Macromolecules
This study aimed to prepare carrageenan/sodium alginate double-stabilized layers of zein nanoparticles loaded with daidzein using ultrasound technology to investigate the effect of ultrasound treatment on the stability of composite nanoparticles and ...
Xue Yang   +5 more
semanticscholar   +1 more source

Daidzein exerts neuroprotective activity against MPTP‐induced Parkinson's disease in experimental mice and lipopolysaccharide‐induced  BV2 microglial cells

Journal of biochemical and molecular toxicology, 2021
Parkinson's disease (PD) ranks as the second most neurodegenerative disease characterized by loss of neurons, bradykinesia, anosmia, sleep disorder, and motor deficiency with increased global prevalence.
Qiong Wu   +4 more
semanticscholar   +1 more source

Dietary daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels.

Virus Research, 2021
MicroRNAs are emerging as critical endogenous regulators of gene function. Aberrant regulation of microRNAs is associated with various human diseases, most importantly cancer.
Yujiao He   +7 more
semanticscholar   +1 more source

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