Results 241 to 250 of about 8,364,200 (274)

Safety of long-term use of daily and long-acting growth hormone in growth hormone-deficient adults on cancer risk

Best Practice & Research Clinical Endocrinology & Metabolism, 2023
Daily injections of recombinant human growth hormone (rhGH) have been used in clinical practice for almost four decades as a replacement therapy in adult patients with GH deficiency (GHD). Long-term adherence to daily injections of rhGH is a clinical concern that may result in reduced therapeutic efficacy, and long-acting GH (LAGH) formulations have ...
Cesar Boguszewski
exaly   +3 more sources

Comparing treatment with daily and long-acting growth hormone formulations in adults with growth hormone deficiency: Challenging issues, benefits, and risks

Best Practice & Research Clinical Endocrinology & Metabolism, 2023
Daily administration of growth hormone (GH) treatment has been in clinical use for treatment for GH deficiency (GHD) in adults for more than 30 years. Numerous studies have demonstrated evidence that GH treatment improves body composition, cardiovascular risk factors and quality of life with few side effects.
exaly   +3 more sources

Growth Response to Daily Subcutaneous Administration of Growth Hormone

Pediatrics International, 1988
AbstractThe effect on growth rate of daily subcutaneous (sc) administration of growth hormone (GH) was studied in seven GH‐deficient children. All patients had been receiving conventional GH treatment (intramuscularly, twice or thrice weekly) for three to six years.
K, Kikuchi, M, Sudo, A, Miyamoto, T, Ohie, C, Mori, H, Mikawa   +5 more
openaire   +2 more sources

Growth Hormone by Daily Injection in Patients Previously Treated for Growth Hormone Deficiency

Southern Medical Journal, 1990
When recombinant-DNA-derived methionyl growth hormone (met-GH) became available for patients resuming treatment, we were able to compare dose intervals in 47 prepubertal children with growth hormone deficiency. Patients were randomly assigned to one or three doses weekly or to daily injections for a total dosage of 0.3 mg/kg weekly.
A L, Rosenbloom, C, Knuth, D, Shulman
openaire   +2 more sources

Impact of Daily Growth Hormone Adherence on Height Velocity Among Children With Growth Hormone Deficiency (GHD)

Endocrine Practice
To describe adherence to daily somatropin treatment and impact on height velocity within 1 year of treatment start among patients with pediatric growth hormone deficiency in a real-world US population.This retrospective cohort study included pediatric patients aged ≥3 years to
Darrin Benjumea, Priti Jhingran, Mona Kelkar   +2 more
exaly   +3 more sources

Metabolic effects of growth hormone administered subcutaneously once or twice daily to growth hormone deficient adults

Clinical Endocrinology, 1994
SummaryOBJECTIVE The aim of this study was to compare the metabolic effects of GH administered subcutaneously either once or twice daily. The actions of GH might depend upon a pulsatlle pattern of serum GH. Pulsatile and continuous intravenous delivery of GH, however, induce similar short‐term metabolic effects in GH deficient patients.
Laursen, Torben, Jørgensen, Jens Otto Lunde; id_orcid 0000-0001-7408-1526, Christiansen, Jens Sandahl   +2 more
openaire   +3 more sources

Daily Variation in Rat Growth Hormone Concentration and the Effect of Stress on Periodicity

Neuroendocrinology, 2008
Groups of normal adult male rats were rapidly decapitated at 3 h intervals for radioimmunoassay determination of pituitary growth hormone (GH) content and plasma GH concentration. Although both pituitary and plasma GH levels varied markedly with the time of day, only the latter variations were statistically significant. The periodicity in plasma GH was
J D, Dunn, W J, Schindler, M D, Hutchins, L E, Scheving, C, Turpen   +4 more
openaire   +2 more sources

Effects of daily 30 mcg d-norgestrel on growth hormone and cortisol

Contraception, 1983
The effects of d-norgestrel on serum growth hormone and cortisol were determined in 9 healthy Thai women, who took 30 mcg d-norgestrel tablet daily for 12 months. Growth hormone (both fasting and during OGTT) and morning cortisol concentrations were measured before and after 6 and 12 months.
P, Virutamasen, C, Wongsrichanalai, K, Channiyom, B, Boonsiri   +3 more
openaire   +2 more sources

Effects of pyridostigmine on spontaneous and growth hormone‐releasing hormone stimulated growth hormone secretion in children on daily glucocorticoid therapy after liver transplantation

Clinical Endocrinology, 1991
SUMMARY objectives We aimed to investigate both nocturnal spontaneous and morning growth hormone (GH)‐releasing hormone (GHRH)‐induced GH secretion in children on daily glucocorticoid treatment after liver transplantation and to evaluate the effect of pyridostigmine (an acetylcholinesterase inhibitor thought to reduce hypothalamic somatostatin tone) on
GIUSTINA, Andrea, Girelli A, ALBERTI, Daniele, Bossoni S, Buzi F, Doga M, Schettino M, Wehrenberg WB   +7 more
openaire   +4 more sources

Effect of daily injections of growth hormone-releasing factor and thyrotropin-releasing hormone on growth and endocrine parameters in chickens

Domestic Animal Endocrinology, 1986
Abstract The control of growth is a complex mechanism regulated by several metabolic hormones including growth hormone (GH) and thyroid hormones. In avian species, as well as in mammals, GH secretion is regulated by hypothalamic hypophysiotropic hormones.
F.C. Buonomo, C.A. Baile
openaire   +1 more source