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Plain language summary - Effective growth hormone replacement with once-weekly somapacitan versus daily growth hormone in children with growth hormone deficiency: 3-year results from REAL 3

, 2022
A plain language summary for the publication Effective growth hormone replacement with once-weekly somapacitan versus daily growth hormone in children with growth hormone deficiency: 3-year results from REAL
Lars Sävendahl (9986312)
core   +1 more source

A phase 2 trial of long-acting TransCon growth hormone in adult GH deficiency

Endocrine Connections, 2017
TransCon growth hormone is a sustained-release human growth hormone prodrug under development in which unmodified growth hormone is transiently linked to a carrier molecule.
Charlotte Höybye, Andreas F H Pfeiffer, Diego Ferone, Jens Sandahl Christiansen, David Gilfoyle, Eva Dam Christoffersen, Eva Mortensen, Jonathan A Leff, Michael Beckert   +8 more
doaj   +1 more source

Growth hormone treatment for adults with Prader-Willi syndrome: another point of view

Orphanet Journal of Rare Diseases, 2021
Growth hormone treatment for children with Prader Willi syndrome (PWS) has shown proven benefits not only in increasing final height but also with positive effects on body composition and motor development.
Harry J. Hirsch, Varda Gross-Tsur
doaj   +1 more source

Developments in the Management of Growth Hormone Deficiency: Clinical Utility of Somapacitan

Drug Design, Development and Therapy
Bradley S Miller,1 Jo Blair,2 Reiko Horikawa,3 Agnès Linglart,4– 7 Kevin CJ Yuen8 1Division of Pediatric Endocrinology, University of Minnesota Medical School, MHealth Fairview Masonic Children’s Hospital, Minneapolis, MN, USA; 2Department of Paediatric ...
Miller BS, Blair J, Horikawa R, Linglart A, Yuen KC   +4 more
doaj   +1 more source

Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: Summary statement of the growth hormone research society workshop on adult growth hormone deficiency [PDF]

, 1998
Based on the increasing body of evidence that adults with GH deficiency (somatotropin deficiency) have impaired health that improves with GH replacement, many countries have already approved the use of GH for replacement therapy in adults with GH ...
Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency, Clemmons, David   +1 more
core   +1 more source

Growth hormone therapy in Turner's syndrome: one versus two daily injections. [PDF]

The Journal of Clinical Endocrinology & Metabolism, 1994
In 44 girls with Turner's syndrome, aged 4.0-15.3 yr, the effects of biosynthetic GH (25 U/m2.week) given as once daily or twice daily injections were compared. During 1 yr of treatment, the growth rate increased similarly by 3.5 +/- 1.3 cm/yr in the once daily group and 2.7 +/- 1.8 cm/yr in the twice daily group.
De Schepper, Jean, Craen, Margarita, Massa, Guy, Heinrichs, Claudine, Maes, Marc, Du Caju, Marc, Rausin, Léon, Bourguignon, Jean-Pierre   +7 more
openaire   +4 more sources

ODP329 Long-term Effect of Daily Growth Hormone Replacement Therapy on Glucose Tolerance in Adult growth Hormone Deficiency [PDF]

J Endocr Soc, 2022
Abstract Background Growth hormone replacement therapy (GHRT) in adults with growth hormone deficiency (AGHD) has shown to improve body composition, lipid and bone metabolism, and quality of life (QOL), but its effect on glucose tolerance can be bidirectional.
Bando, Hironori, Fukuoka, Hidenori, Iguchi, Genzo, Kanie, Keitaro, Ogawa, Wataru, Shichi, Hiroki, Suzuki, Masaki, Takahashi, Michiko, Takahashi, Yutaka, Urai, Shin, Yamamoto, Naoki, Oi, Yuka, Yamamoto, Masaaki, Sasaki, Yuriko   +13 more
europepmc   +2 more sources

RELATIONSHIP OF GROWTH HORMONE RECEPTOR GENE WITH SOME OF PRODUCTIVE TRAITS OF COMMON CARP Cyprinus carpio

The Iraqi Journal of Agricultural science, 2023
This study was aimed of determining the relationship of polymorphism of the growth hormone receptor gene with some of growth traits (daily growth rate, relative and specific growth, ratio and efficiency of feed conversion) in 45 samples of common carp ...
Yousef T. A., M. S. Al-Khshali
doaj   +1 more source

Efficacy and Safety of Somapacitan versus Daily Growth Hormone in Children with Growth Hormone Deficiency: A Pooled Analysis of Randomised Trial Data.

Horm Res Paediatr
Background: Several studies have individually suggested that somapacitan, a once-weekly growth hormone (GH) treatment, has similar efficacy and safety to once-daily GH in children with GH deficiency. Objective: To assess the efficacy and safety of somapacitan vs daily GH after 52 and 156 weeks of treatment using pooled data from the REAL 3, REAL 4, and
Sävendahl L, Maniatis AK, Pietropoli A, Kelepouris N, Højby M, Ferran JM, Fu J, Mori J, Wabitsch M, Miller BS.   +9 more
europepmc   +2 more sources

Molecular basis of growth hormone daily mRNA and protein synthesis in rats

Life Sciences, 2018
Daily and seasonal rhythms coordinate the endocrine and metabolic functions. The pituitary gland is the master regulator of several endocrine activities, and its function is classically regulated by endocrine signals from its target glands as well as from the hypothalamus. The growth hormone (GH) produced and secreted by the anterior pituitary presents
T. de Castro Barbosa, R.B. Salgueiro, C. Serrano-Nascimento, F.G. Amaral, J. Cipolla-Neto, M.T. Nunes   +5 more
openaire   +2 more sources