Precision Dosing for Pediatric Growth Hormone Deficiency With Daily and Weekly Growth Hormone [PDF]
MedCommPediatric growth hormone deficiency (GHD) typically requires daily injections of recombinant human growth hormone (rhGH). Long‐acting PEGylated recombinant human growth hormone (PEG‐rhGH) formulations have been developed to reduce injection frequency and
Wei Wu +12 more
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Drug Design, Development and Therapy, 2015 Ling Hou,1,* Zhi-hang Chen,2,* Dong Liu,3 Yuan-guo Cheng,2 Xiao-ping Luo1 1Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 2Department of Pharmacy, Beijing Institute of ...
Hou L, Chen ZH, Liu D, Cheng YG, Luo XP
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Retraction: Effect of weekly long-acting growth hormone replacement therapy compared to daily growth hormone on children with short stature: a meta-analysis [PDF]
Frontiers in Endocrinology, 2023 Frontiers Editorial Office
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Frontiers in Endocrinology, 2023 IntroductionThe standard of care for pediatric growth hormone deficiency (pGHD) is once-daily recombinant human growth hormone (rhGH). Somatrogon, a long-acting rhGH, requires less frequent, once-weekly, dosing.
Roy Gomez +8 more
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Comparison of efficacy and safety between long-acting growth hormone and short-acting growth hormone in isolated growth hormone deficiency: a systematic review and meta-analysis of 16 randomized controlled trials involving 2,435 pediatric patients [PDF]
Frontiers in PediatricsObjectiveTo comprehensively compare the efficacy and safety of long-acting human growth hormone (LAGH) preparations with conventional short-acting daily growth hormone (SA-GH) in children with isolated growth hormone deficiency (GHD), and explore ...
Zhen-Zhen Shen +4 more
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Scientific ReportsThis systematic review aims to summarize the therapeutic benefits and safety profile of long-acting PEGylated recombinant human growth hormone (PEG‑rhGH) compared with daily recombinant human growth hormone (DGH) in pediatric growth hormone deficiency ...
Jun Zhang +3 more
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Real-World Canadian Insights into Pediatric Growth Hormone Deficiency: Perspectives on Daily and Long-Acting Growth Hormone from Patients, Caregivers, and Healthcare Providers [PDF]
Patient Preference and AdherenceDavid Nguyen,1 Ufuk Coşkun,2 Chantal Cadieux,1 Jamie Harvey,3 Olga Moshkovich,2 Neha Durgam,2 M. Alex Bellenger,2 Vicky Turner,4 Duygu Alpan,2 Triza Brion21Pfizer, Kirkland, Quebec, Canada; 2ICON Clinical Research, Blue Bell, PA, USA; 3The ...
Nguyen D +9 more
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More Favorable Metabolic Impact of Three-Times-Weekly versus Daily Growth Hormone Treatment in Naïve GH-Deficient Children [PDF]
International Journal of Endocrinology, 2017 Objective. To evaluate whether two different regimens of weekly injections could lead to similar auxological and metabolic effects in children with growth hormone deficiency (GHD). Design.
Alessandro Ciresi +5 more
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Developments in administration of growth hormone treatment: focus on Norditropin® Flexpro®
Patient Preference and Adherence, 2011 Kevin CJ Yuen1, Rakesh Amin21Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA; 2Barts and The London Children’s Hospital, London, UKAbstract ...
Kevin CJ Yuen, Rakesh Amin
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Population Pharmacokinetics and Pharmacodynamics of Once-Daily Growth Hormone Norditropin® in Children and Adults. [PDF]
Clin Pharmacokinet, 2021 Once-daily injectable recombinant human growth hormone (GH) formulations (e.g. Norditropin®; Novo Nordisk A/S) are used to treat GH deficiency in children and adults, with much of the therapeutic effect mediated via the insulin-like growth factor-I (IGF-I) response.
Papathanasiou T +4 more
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