Lipoatrophy associated with daily growth hormone injections [PDF]
Endocrinology, Diabetes & Metabolism Case Reports, 2021 Recombinant human growth hormone therapy (rhGH) has been available since 1985 for a variety of conditions and has expanded the indications for rhGH therapy and the number of patients receiving therapy.
Priya Darshani Chhiba, David Segal
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Persistence with daily growth hormone among children and adolescents with growth hormone deficiency in the UK [PDF]
Frontiers in Endocrinology, 2022 BackgroundChildren with growth hormone deficiency (GHD) are treated with daily somatropin injections; however, poor treatment persistence and adherence have been recognized previously and have been shown to negatively impact growth outcomes.
Jane Loftus +10 more
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RETRACTED: Effect of Weekly Long-Acting Growth Hormone Replacement Therapy Compared to Daily Growth Hormone on Children With Short Stature: A Meta-Analysis [PDF]
Frontiers in Endocrinology, 2021 BackgroundWe performed a meta-analysis to evaluate the efficacy and safety of weekly long-acting growth hormone replacement therapy compared to daily growth hormone in children with short stature.MethodsA systematic literature search up to April 2021 was
Liyan Ma +6 more
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Pharmacological Research, 2023 We evaluated the efficacy, safety, adherence, quality of life (QoL) and cost-effectiveness of long-acting growth hormone (LAGH) vs daily growth hormone (GH) preparations in the treatment of growth hormone deficiency (GHD) in children. Systematic searches
Chiara Mameli +11 more
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Efficacy in Japanese adults with growth hormone deficiency receiving weekly somapacitan or daily growth hormone: results from phase 3 REAL 1 trial [PDF]
Frontiers in EndocrinologyIntroductionSomapacitan is a long-acting growth hormone (GH) derivative approved for once-weekly treatment of adult GH deficiency (AGHD). This study aimed to evaluate the efficacy and safety of somapacitan and daily GH in Japanese individuals with AGHD ...
Fumio Otsuka +5 more
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Persistence with daily growth hormone among children and adolescents with growth hormone deficiency in Japan [PDF]
PLoS ONEBackground Pediatric growth hormone deficiency (pGHD) is treated with daily somatropin (recombinant human growth hormone) injections. High rates of discontinuation and poor adherence to treatment, which are associated with worse growth outcomes, have been documented previously, for example in the US and Europe ...
Jane Loftus +7 more
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Similar safety and efficacy in previously treated adults with growth hormone deficiency randomized to once-weekly somapacitan or daily growth hormone. [PDF]
Clin Endocrinol (Oxf), 2020 AbstractObjectiveSomapacitan is a long‐acting, reversible albumin‐binding growth hormone (GH) derivative in development. This study aimed to evaluate the safety and efficacy of once‐weekly somapacitan versus daily GH over 52 weeks in Japanese patients with adult growth hormone deficiency (AGHD).DesignPhase 3, multicentre, randomized, parallel‐group ...
Otsuka F +5 more
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Long‐Acting Growth Hormone Versus Daily Growth Hormone for Growth Hormone Deficiency Patients: A Network Meta‐Analysis of Clinical Trials [PDF]
Endocrinology, Diabetes & MetabolismIntroduction Current guidelines recognize daily recombinant human growth hormone (rhGH) as standard care and long‐acting growth hormone (LAGH) as an alternative for paediatric growth hormone deficiency (CHD).
Amir Abadi +8 more
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Weekly long-acting growth hormone versus daily growth hormone therapy on quality of life, efficacy, and safety in children with short stature: a systematic review and meta-analysis [PDF]
Frontiers in EndocrinologyBackgroundThis meta-analysis aims to compare the QoL, efficacy, and safety of once-weekly LAGH versus daily GH in children with short stature.MethodsWe systematically searched PubMed, Embase, the Cochrane Library, and Web of Science from inception to ...
Fan Liu +4 more
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A database study of the safety and effectiveness of daily growth hormone in treating more than 80,000 children with growth disorders worldwide: a plain language summary of publication [PDF]
Therapeutic Advances in Endocrinology and MetabolismSummary Researchers looked at data from the largest and longest-running database of children with growth disorders who were treated with daily injections of a brand of growth hormone called Genotropin .
Mohamad Maghnie +19 more
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