Results 101 to 110 of about 391,464 (281)

The bone tissue remodeling in the proximal femur under the variations of hip joint daily loading history

open access: yesРоссийский журнал биомеханики, 2001
С помощью двумерной конечноэлементной модели проксимального отдела бедра, учитывающей адаптацию губчатой костной ткани с использованием деформационного стимула внутренней перестройки, исследуется изменение распределения модуля упругости костной ткани при изменении характера нагрузки на тазобедренный сустав.
Akulich, Yu   +3 more
openaire   +1 more source

Design and Testing of a Structural Monitoring System in an Almería-Type Tensioned Structure Greenhouse [PDF]

open access: yes, 2020
Greenhouse cultivation has gained a special importance in recent years and become the basis of the economy in south-eastern Spain. The structures used are light and, due to weather events, often collapse completely or partially, which has generated ...
Marín Membrive, Patricia   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

BiKAN-LoadNet: An Electric Load Forecasting Model Based on Bidirectional LSTM and Kolmogorov–Arnold Networks

open access: yesIEEE Access
Electric load forecasting plays an important role in smart grid scheduling and operation optimization. However, existing methods still have limitations in multi-target joint modeling, integration of external weather features, and capturing nonlinear ...
Liang He, Belyaevsky Roman Vladimirovich
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Dynamic load management and optimum sizing of stand-alone hybrid PV/Wind system. [PDF]

open access: yes, 2015
Simulation algorithms for the sizing of stand-alone hybrid PV/Wind systems are a powerful tool in evaluating the optimum configuration that would cover the energy demand with a predefined reliability level at the lowest cost.
Diamantopoulos, N.   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Variation in the ambulatory blood pressure response to daily work load--the moderating role of job control.

open access: yesScandinavian journal of work, environment & health, 1998
This quasi-experimental study tested the ambulatory blood pressure responsivity to daily variation in the work load of the same workers and examined whether this responsivity is moderated by perceived job control.The subjects were 79 nonshift, normotensive men who reported nearly almost equal occurrences of low and high work load in a typical workday ...
S, Melamed   +4 more
openaire   +1 more source

A Modular Low-clearance Wrist Orthosis for Improving Wrist Motion in Children with Cerebral Palsy [PDF]

open access: yes, 2014
Children with Cerebral Palsy (CP) often exhibit impairments in the coordination of the grip and lift phases of arm movements that directly impact their ability to perform activities of daily living (ADLs).
Beardsley, Scott A.   +3 more
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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