Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Conversion of chemical scrubbers to biotrickling filters for VOCs and H2S treatment at low contact times [PDF]
, 2015 The purpose of this work was to evaluate the technical and economical feasibility of converting three chemical scrubbers in series to biotrickling filters (BTFs) for the simultaneous removal of H2S and volatile organic compounds (VOCs). The conversion of
Dorado Castaño, Antonio David +4 more
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Modelling crown snow loads in Finland: a comparison of two methods
Silva Fennica, 2014 The spatial occurrence of heavy crown snow loads in Finland between 1961 and 2010 is studied by using for the first time a model that classifies the snow load into four different types: rime, dry snow, wet snow and frozen snow.
Lehtonen, Ilari +3 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Eutrophication mitigation in rivers: 30 years of trends in spatial and seasonal patterns of biogeochemistry of the Loire River (1980–2012) [PDF]
Biogeosciences, 2015 Trends and seasonality analysis from 1980 onward and longitudinal distribution, from headwaters to estuary, of chlorophyll a, nitrate and phosphate were investigated in the eutrophic Loire River.
C. Minaudo +4 more
doaj +1 more source
Hydrological Alteration Index as an Indicator of the Calibration Complexity of Water Quantity and Quality Modeling in the Context of Global Change [PDF]
, 2019 Modeling is a useful way to understand human and climate change impacts on the water resources of agricultural watersheds. Calibration and validation methodologies are crucial in forecasting assessments.
Bodoque, José María +12 more
core +6 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
SAMPLING OF THE PLAN OF REPAIRS OF THE MAIN EQUIPMENT IN THE ELECTRICAL POWER SYSTEM
Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2017 The main aspects of creation of the formal-and-functional mathematical models supporting a system for prompt resolution of repair requires in a complex electric power system are considered in the article.
O. I. Alexandrov
doaj +1 more source