Results 81 to 90 of about 62,885 (274)

Multi-State Load Models for Distribution System Analysis [PDF]

, 2011
Recent work in the field of distribution system analysis has shown that the traditional method of peak load analysis is not adequate for the evaluation of emerging distribution system technologies.
Kevin P. Schneider, Jason C. Fuller, Schneider, Kevin P., David P. Chassin, Chassin, David P., Fuller, Jason C.   +5 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Generating realistic building electrical load profiles through the Generative Adversarial Network (GAN) [PDF]

, 2020
Building electrical load profiles can improve understanding of building energy efficiency, demand flexibility, and building-grid interactions. Current approaches to generating load profiles are time-consuming and not capable of reflecting the dynamic and
Wang, Zhe, Wang, Z, Hong, Tianzhen, Hong, T   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Dynamic thermo-mechanical responses of road-soft ground system under vehicle load and daily temperature variation

Journal of Rock Mechanics and Geotechnical Engineering
A complete road-soft ground model is established in this paper to study the dynamic responses caused by vehicle loads and/or daily temperature variation. A dynamic thermo-elastic model is applied to capturing the behavior of the rigid pavement, the base course, and the subgrade, while the soft ground is characterized using a dynamic thermo-poroelastic ...
Chuxuan Tang, Jie Liu, Zheng Lu, Yang Zhao, Jing Zhang, Yinuo Feng   +5 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Modelling crown snow loads in Finland: a comparison of two methods

Silva Fennica, 2014
The spatial occurrence of heavy crown snow loads in Finland between 1961 and 2010 is studied by using for the first time a model that classifies the snow load into four different types: rime, dry snow, wet snow and frozen snow.
Lehtonen, Ilari, Hoppula, Petri, Pirinen, Pentti, Gregow, Hilppa   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A Multi-Scale Framework for Deconstructing Residential Energy Consumption Heterogeneity Using Gaussian Mixture Models

Buildings
Residential energy consumption exhibits substantial behavioral uncertainty and temporal heterogeneity, which pose challenges for demand-side management and residential load profiling.
Jinyong She, Jintao Xu, Kaida Chen, Senhong Cai   +3 more
doaj   +1 more source