Results 71 to 80 of about 62,885 (274)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Weekly Load Variations of Distance-Based Variables in Professional Soccer Players: A Full-Season Study [PDF]

, 2020
The aim of this study was two-fold: (1) to analyze the variations of acute load, training monotony, and training strain among early (pre-season), mid (first half of season), and end season (second half of season) periods; (2) to compare these training ...
Silva, Rui, Filipe Manuel Clemente, José Afonso, Clemente, Filipe Manuel, Mendes, Bruno, Rui Silva, Castillo, Daniel, Los Arcos Larumbe, Asier, Bruno Mendes, Daniel Castillo, Afonso, José, Asier Los Arcos   +11 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Extensive Comparative Analysis Of Two Building Energy Simulation Codes For Southern Europe Climates: Heating And Cooling Energy Needs and Peak Loads Calculation In TRNSYS And EnergyPlus [PDF]

, 2012
In order to evaluate the energy performance of buildings, both in heating and in cooling periods, the simulation codes can be used. Moreover, in accordance with the technical Standard EN ISO 13790:2008, the simulation codes can be employed for refining ...
Andrea Gasparella, Gasparella, Andrea, Pernigotto, Giovanni   +2 more
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Performance evaluation of aluminum-in-pot evaporative cooler

Revista Brasileira de Engenharia de Biossistemas
Cooling applications by refrigeration and air-conditioning require electricity as a source of energy not abundantly available in sub-Saharan African countries.
Olalekan Popoola, Haruna Issa, Hassan Ibrahim, Peter Omoniyi, Isaac Adegun   +4 more
doaj   +1 more source

Modelling electricity demand with representative load curves [PDF]

, 1999
Models for electricity planning require inclusion of demand. Depending on the type of planning, the demand is usually represented as an annual demand for electricity (GWh), a peak demand (MW) or in the form of annual load-duration curves.
Balachandra, P., Balachandra, P, Chandru, V, Chandru, Vijay   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Tracking Day-To-Day Achilles Tendon Loading Progression During Rupture Recovery: A Case Study

Foot & Ankle Orthopaedics, 2022
Category: Sports; Basic Sciences/Biologics Introduction/Purpose: Achilles tendon rupture patients often suffer long-term functional deficits. Although progressive tendon loading improves healing, it is difficult to reliably measure in the real world and ...
Josh R. Baxter, Ke Song, Stephanie G. Cone, Jennifer A. Zellers PhD, DPT, Darryl G. Thelen PhD   +4 more
doaj   +1 more source

Analysing climate impact on energy demand using the MOLAND model [PDF]

, 2008
The importance and contribution of climate to energy demand are discussed. A linear regression model is developed to analyse future energy demand corresponding to climate change.
Twumasi, Bright Osei, Liu, Xiaochen
core