Results 91 to 100 of about 286,854 (260)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Variations in Maximum and Minimum Temperature in Mount Qomolangma during 1971–2020

Atmosphere
Based on the daily maximum and minimum temperature observational data during 1971–2020, the variabilities of the maximum and minimum temperature of Mount Qomolangma are analyzed.
Shunjiu Wang
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Night-Time Temperature Reprieves Enhance the Thermal Tolerance of a Symbiotic Cnidarian

Frontiers in Marine Science, 2019
Responses of cnidarian-Symbiodiniaceae associations to warming are determined, in part, by high-frequency temperature variability. Yet, the role of such variability in determining specific maximum temperature thresholds of cnidarian holobionts (the ...
Shannon G. Klein, Kylie A. Pitt, Cathy H. Lucas, Shiou-Han Hung, Sebastian Schmidt-Roach, Manuel Aranda, Carlos M. Duarte   +6 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Investigating the Impact of Climate Change on Extreme Temperature and Precipitation in the Sefidrood Basin Based on CMIP6 Models [PDF]

علوم آب و خاک
In the present study, the impact of climate change on maximum temperature and daily precipitation in 16 weather stations was investigated in the Sefidrood Basin from 2023 to 2052.
M.J. Zareian, R. Seraj Ebrahimi, H. Dehban   +2 more
doaj  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Radial growth and its temporal stability of Dahurian larch in the southern boreal forest: Divergent trends during climate warming and warming hiatus

Forest Ecosystems
Climate warming has reshaped the structure and function of global boreal forest with expected negative impacts at its southern margins. A warming hiatus has occurred in many high-latitude regions in recent decades, but its impacts on tree growth in the ...
Zhongtong Peng, Enzai Du, Yang Tang, Tao He, Yuehan Tian   +4 more
doaj   +1 more source

Trends in temperature and growing season length in idaho-usa during the past few decades

Revista Brasileira de Meteorologia, 2015
This study attempts to provide new information on seasonal and annual trends, on a regional scale, using records of daily air temperature over Idaho, USA, through the analysis of the Growing Season Length (GSL), and maximum and minimum air temperature ...
Carlos Antonio Costa dos Santos, Tantravahi Venkata Ramana Rao, Ricardo Alves de Olinda   +2 more
doaj   +1 more source