Results 71 to 80 of about 963,699 (298)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The correlation between the daily incidence of varicella and meteorological factors in Jiangxi province from 2015 to 2021: a surveillance data analysis

Zhongguo gonggong weisheng
ObjectiveTo understand the correlation between the incidence of varicella and meteorological factors in Jiangxi province from 2015 to 2021, and to provide a reference for meteorological prediction and early warning of varicella incidence.
Xing YE, Chengfeng ZHANG, Huijian CHENG, Sheng DING, Weijie FU   +4 more
doaj   +1 more source

October Mean Daily Maximum Temperatures

, 2010
The map shows the mean daily maximum temperatures for October. Much of southern Canada experiences maximum temperatures in October above 10°C, whereas maximum temperatures across most of the northern territories are below zero. Only the southern portions of the Yukon and the Northwest Territories have maximum temperatures in October that exceed 0ºC.
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Study on Forecasting Model of Maximum Daily Power Load in Beijing Area

Zhongguo dianli, 2019
The characteristics of maximum daily power load and the dependence of maximum daily power load on meteorological factors are analyzed in this paper based on the records of the power load and auto weather station meteorological data of Beijing from 2009 ...
Yuheng SHI, Na ZHAO, Ling WANG, Lijia XU, Jie ZHOU, Qian LIN, Yuan QIAO   +6 more
doaj   +1 more source

January Mean Daily Maximum Temperatures

, 2010
The map shows the mean daily maximum temperatures for January. Weak or no sunshine means there is minimal diurnal variation between the maximum and minimum temperatures in January. The far north remains in an icy grip, with maximum temperatures around -30ºC or colder across parts of Nunavut.
openaire   +1 more source

The association of cold weather and all-cause and cause-specific mortality in the island of Ireland between 1984 and 2007 [PDF]

, 2014
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
A Analitis, A Atsumi, AG Barnett, AG Barnett, AG Barnett, AJ McMichael, AL Braga, Ariana Zeka, B Revich, BG Anderson, C Liddell, CB Field, D Levy, GC Donaldson, H McAvoy, Helen McAvoy, I Gemmell, J Diaz, J Schwartz, J Schwartz, J Schwartz, J Schwartz, JD Healy, JD Healy, JP Buckley, JT Lee, K Ebi, M Carder, M Maclure, ME Payton, MS Goldberg, P Goodman, Patrick Goodman, PG Goodman, PL Kinney, PL Staddon, R Walker, S Hajat, Stephen Browne, T Lumley, TF Bateson, TF Bateson, The Marmot Review Team, U Dubois, W Yu, Y Guo, Y Lu, YC Hong   +47 more
core   +3 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Assessing the Volatility of Daily Maximum Temperature across Germany between 1990 and 2022

Atmosphere
Climate change causes a global rise in mean air temperature and an increased frequency of temperature extremes. Recent studies link sharp temperature changes between consecutive days to increased mortality, reduced economic growth, and negative effects ...
Elisa Jordan, Ankit Shekhar, Mana Gharun
doaj   +1 more source

Associations between daily ambient temperature and sedentary time among children 4-6 years old in Mexico City.

PLoS ONE, 2020
BackgroundSedentary behavior is a worldwide public health concern. There is consistent and growing evidence linking sedentary behavior to mortality and morbidity.
Sandy Wong, Alejandra Cantoral, Martha María Téllez-Rojo, Ivan Pantic, Emily Oken, Katherine Svensson, Michael Dorman, Iván Gutiérrez-Avila, Johnathan Rush, Nia McRae, Robert O Wright, Andrea A Baccarelli, Itai Kloog, Allan C Just   +13 more
doaj   +1 more source