Results 61 to 70 of about 4,714,251 (292)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Milking frequency effect on rumination daily profile of dairy cows [PDF]
Ciência Rural: Rumination monitoring assesses dairy cows’ health, reproduction, and welfare status. The present study evaluated whether increasing the milking frequency affects dairy cows’ milk yield and daily rumination profile.
Amanda Uliana Manfio +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
AnimalsThis retrospective cohort study examined the association between delayed milk ejection (DME), defined as bimodal milk flow, and milk yield in dairy cows milked with an automated milking system (AMS).
Matthias Wieland, Heleen ten Have
doaj +1 more source
Side preference of dairy cows in the milking parlour and its impact on daily milk yield
Veterinarski glasnik, 2021 Monitoring of the side preference of dairy cows in the milking parlour was performed in a group of 40 dairy cows (Czech spotted cattle). Twenty milking sessions were evaluated for each cow, and the composition of the monitored group of cows was kept constant. A significant side preference was found in 26 (65%) cows.
Vendula Rencinova +2 more
openaire +3 more sources
Average daily milk yield and milk composition during P1.
, 2016 Average daily milk yield and milk composition during P1.
Florence Jaffrezic (2220268) +15 more
core +1 more source
Effects of peripartum biotin supplementation of dairy cows on milk production and milk composition with emphasis on fatty acids profile [PDF]
, 2008 Forty Holstein dairy cows receiving a 38% concentrate diet based on maize silage were assigned to either a control group, either a biotin group, receiving 20 mg of biotin per day from 15 days before expected calving date and for 120 days after calving ...
Enjalbert, Francis +2 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Mljekarstvo, 2012 The objective of this study was to analyse the effect of stage of lactation, parity, litter size, and lambing season on daily milk production and fat and protein content in Istrian sheep.
Marija Špehar +4 more
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source