Results 51 to 60 of about 874,081 (300)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Improving location prediction services for new users with probabilistic latent semantic analysis
, 2012 Location prediction systems that attempt to determine the mobility patterns of individuals in their daily lives have become increasingly common in recent years.
Jennings, Nicholas R. +2 more
core +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Journal of Ayurveda and Integrative Medicine, 2014 Background: Systemic sclerosis (SSc) is a chronic, multisystem connective tissue disorder characterized by autoimmune activation, microvascular endothelium damage, and excessive collagen proliferation.
Kunavut Vannajak +4 more
doaj +1 more source
Internet networks user’s daily mobility in social space of city [PDF]
, 2015 В статье рассматривается влияние повседневной мобильности интернет пользователей на процессы группообразования в мегаполисе. Определяются виды повседневной мобильности и ресурсы, обеспечивающие её осуществление.
Danilova, A. V. +1 more
core
, 2014 In recent years, mobility models have been reconsidered based on findings by analyzing some big datasets collected by GPS sensors, cellphone call records, and Geotagging.
Fujihara, Akihiro, Miwa, Hiroyoshi
core +1 more source
Analysis of a public repository for the study of automatic fall detection algorithms [PDF]
, 2018 The use of publicly available repositories containing movement traces of real or experimental subjects is a key aspect to define an evaluation framework that allows a systematic assessment of wearable fall detection systems.
Cano-Garcia, Jose Manuel +2 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Older adults, falls and technologies for independent living: a life space approach [PDF]
, 2011 This paper draws attention to the need for further understanding of the fine details of routine and taken-for-granted daily activities and mobility. It argues that such understanding is critical if technologies designed to mitigate the negative impacts ...
BEN DROMEY +16 more
core +1 more source