Results 91 to 100 of about 4,279 (197)

Real‐world evidence in the cloud: Tutorial on developing an end‐to‐end data and analytics pipeline using Amazon Web Services resources

Clinical and Translational Science, Volume 17, Issue 12, December 2024.
Abstract In the rapidly evolving landscape of healthcare and drug development, the ability to efficiently collect, process, and analyze large volumes of real‐world data (RWD) is critical for advancing drug development. This article provides a blueprint for establishing an end‐to‐end data and analytics pipeline in a cloud‐based environment. The pipeline
Wes Anderson, Roopal Bhatnagar, Keith Scollick, Marco Schito, Ramona Walls, Jagdeep T. Podichetty   +5 more
wiley   +1 more source

Exploiting gene regulation as an approach to identify, analyze and utilize the biosynthetic pathways of the glycopeptide ristomycin A and the zincophore [S,S]-EDDS in Amycolatopsis japonicum [PDF]

, 2017
The microbial secondary metabolism is a rich source for valuable products that have found their way into various clinical and industrial applications. A particularly productive bacterial genus for the discovery of natural products is Amycolatopsis.
Spohn, Marius
core   +1 more source

New developments in the treatment of acute bacterial skin and skin structure infections: considerations for the effective use of dalbavancin

Therapeutics and Clinical Risk Management, 2016
Janelle J Juul, Caitlin F Mullins, William J Peppard, Angela M Huang Department of Pharmacy, Froedtert & the Medical College of Wisconsin, Milwaukee, WI, USA Abstract: Dalbavancin, an intravenous glycopeptide, was approved by the US Food and Drug ...
Juul JJ, Mullins CF, Peppard WJ, Huang AM   +3 more
doaj  

Dalbavancin Sequential Therapy for Gram-Positive Bloodstream Infection: A Multicenter Observational Study

Infectious Diseases and Therapy
Introduction Long-acting lipoglycopeptides such as dalbavancin may have utility in patients with Gram-positive bloodstream infections (BSI), particularly in those with barriers to discharge or who require prolonged parenteral antibiotic courses.
Nicholas Rebold, Sara Alosaimy, Jeffrey C. Pearson, Brandon Dionne, Ahmad Taqi, Abdalhamid Lagnf, Kristen Lucas, Mark Biagi, Nicholas Lombardo, Joshua Eudy, Daniel T. Anderson, Monica V. Mahoney, Wesley D. Kufel, Joseph A. D’Antonio, Bruce M. Jones, Jeremy J. Frens, Tyler Baumeister, Matthew Geriak, George Sakoulas, Dimitrios Farmakiotis, Dino Delaportas, Jeremy Larew, Michael P. Veve, Michael J. Rybak   +23 more
doaj   +1 more source

Successful treatment of Enterococcus faecalis bacteremia with dalbavancin as an outpatient in an intravenous drug user

International Journal of Infectious Diseases, 2018
This report describes the treatment of a 35-year-old male who presented to the emergency department with an empyema, and who had a long hospital course complicated by a catheter-related bloodstream infection and a history of intravenous drug use.
Bruce M. Jones, Chelsea Keedy, Melissa Wynn   +2 more
doaj   +1 more source

Bacteriostatic versus bactericidal antibiotics for patients with serious bacterial infections: systematic review and meta-analysis [PDF]

, 2017
Objectives Antibiotics are commonly classified into bactericidal and bacteriostatic agents based on their antimicrobial action. We aimed to assess whether this distinction is clinically relevant.
Kuster, Stefan P., Nemeth, Johannes, Oesch, Gabriela   +2 more
core  

Questioning the Design of Non‐Inferiority Trials: The Strange Case for Therapeutic Drug Monitoring Absence in Phase III Trials

Clinical Pharmacology &Therapeutics, Volume 117, Issue 1, Page 25-27, January 2025.
Florian Lemaitre, Sébastien Lalanne, Marie‐Clémence Verdier   +2 more
wiley   +1 more source

Strategies to Stabilize Dalbavancin in Aqueous Solutions; Section-2: The Effects of 2 Hydroxypropyl-β-Cyclodextrin and Acetate Buffer with and Without Divalent Metal Ions

Pharmaceutics
Objectives: The effect of 2-hydroxpropyl-β-cyclodextrin (2HPβCD) with or without divalent metal ions (Ca2+, Mg2+, and Zn2+) on the stability of dalbavancin in acetate buffer was investigated.
Sardar M. Jakaria, David E. Budil, James Murtagh, Graham Revilla   +3 more
doaj   +1 more source

Real-life experience with IV dalbavancin in Canada; results from the CLEAR (Canadian LEadership on Antimicrobial Real-life usage) registry

Journal of Global Antimicrobial Resistance
: Objectives: We report the use of IV dalbavancin in Canadian patients using data captured by the national CLEAR registry. Methods: The CLEAR registry uses the web-based data management program, REDCap™ (online survey https://rcsurvey.radyfhs.umanitoba ...
George Zhanel, Michael Silverman, Janhavi Malhotra, Melanie Baxter, Reza Rahimi, Neal Irfan, Gabriel Girouard, Rita Dhami, Melissa Kucey, Vida Stankus, Kristin Schmidt, Sébastien Poulin, William Connors, Carlo Tascini, Andrew Walkty, James Karlowsky   +15 more
doaj   +1 more source

Molecular identification and evaluation of antibiotic resistance of coagulase negative Staphylococcus isolated from Neonatal Sepsis hospitalized at Gharazi Hospital in Sirjan, Kerman [PDF]

, 2017
Background and aims: Sepsis is one of the serious infectious diseases in the neonates and infants that is potentially life threatening. The aim of the current study was to identify coagulase negative Staphylococcus and their antibiotic resistance ...
Forouzandeh, Zahra., Kheyrkhah, Babak., Soltani Banavandi, Mohammad Javad.   +2 more
core