Results 71 to 80 of about 4,279 (197)

The Role of ACE2 in SARS‐CoV‐2 Infection, Pathogenesis, and Antiviral Interventions

Journal of Medical Virology, Volume 97, Issue 12, December 2025.
ABSTRACT The devastating clinical, psychological, and economic impact of the COVID‐19 pandemic, caused by global spread of the second Severe Acute Respiratory Syndrome Coronavirus (SARS‐CoV‐2), has engendered a massive response from the scientific community to rapidly understand the biology of SARS‐CoV‐2 and to develop interventions to prevent ...
Michael A. McVoy, Apparao B. Kummarapurugu   +1 more
wiley   +1 more source

Role of Extracellular DNA in Dalbavancin Activity against Methicillin-Resistant Staphylococcus aureus (MRSA) Biofilms in Patients with Skin and Soft Tissue Infections

Microbiology Spectrum, 2022
Methicillin-resistant Staphylococcus aureus (MRSA) has become the leading cause of skin and soft tissue infections (SSTIs). Biofilm production further complicates patient treatment, contributing to increased bacterial persistence and antibiotic tolerance.
Francesca Sivori, Ilaria Cavallo, Daniela Kovacs, Maria Guembe, Isabella Sperduti, Mauro Truglio, Martina Pasqua, Grazia Prignano, Arianna Mastrofrancesco, Luigi Toma, Fulvia Pimpinelli, Aldo Morrone, Fabrizio Ensoli, Enea Gino Di Domenico   +13 more
doaj   +1 more source

A genomic, transcriptomic and proteomic look at the GE2270 producer Planobispora rosea, an uncommon actinomycete [PDF]

, 2015
We report the genome sequence of Planobispora rosea ATCC 53733, a mycelium-forming soil-dweller belonging to one of the lesser studied genera of Actinobacteria and producing the thiopeptide GE2270. The P. rosea genome presents considerable convergence in
Alt, S., Bordoni, R., Corti, G., Cruz, J., De Bellis, G., Donadio, S., GALLO, Giuseppe, Peano, C., Petiti, L., PUGLIA, Anna Maria, Salzano, A., Scaloni, A., Sosio, M., Tocchetti, A.   +13 more
core   +4 more sources

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Dalbavancin to facilitate early discharge in the treatment of complex musculoskeletal infections: a multi-centre real-life application [PDF]

Journal of Bone and Joint Infection
Dalbavancin is a lipoglycopeptide with a half-life of 14 d, significantly reducing the need for daily antibiotic dosing. Although dalbavancin is approved for acute bacterial skin and skin structure infections, its off-label use in complex musculoskeletal
T. Azamgarhi, S. Warren, A. Scobie, N. Karunaharan, C. Perez-Sanchez, R. Houghton, S. Hassan, J. Lourtet-Hascoët, J. Lourtet-Hascoët, H. Kershaw, P. Sendi, K. Saeed, K. Saeed   +12 more
doaj   +1 more source

Managing the Complex Intersection Between Substance Use Disorders and Infectious Diseases

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 3, March 2026.
Karissa Chow, Amanda Binkley, Jessica Meisner, Samantha Huo, Matthew Hinton   +4 more
wiley   +1 more source

Dalbavancin utilization registry investigating value and effectiveness (DRIVE): Outcomes report on real-world use

Clinical Infection in Practice
Objectives: Dalbavancin has potent activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus, and is approved for treatment of acute bacterial skin and skin structure infections (ABSSSI).
Bruce M. Jones, Kerry O. Cleveland, Pedro L. Gonzalez, Urania Rappo, Todd Riccobene, Rosie D. Lyles   +5 more
doaj   +1 more source

Decreases in Antimicrobial Use Associated With Multihospital Implementation of Electronic Antimicrobial Stewardship Tools. [PDF]

, 2020
BackgroundAntimicrobial stewards may benefit from comparative data to inform interventions that promote optimal inpatient antimicrobial use.MethodsAntimicrobial stewards from 8 geographically dispersed Veterans Affairs (VA) inpatient facilities ...
Butler, Jorie M, Chou, Ann F, Glassman, Peter A, Goetz, Matthew Bidwell, Graber, Christopher J, Jones, Makoto M, Madaras-Kelly, Karl, Samore, Matthew H, Weir, Charlene, Youn, Sarah Y, Zhang, Yue   +10 more
core   +1 more source

Systematic review and meta-analysis of the significance of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates [PDF]

, 2011
The prevalence of heteroresistant vancomycin-intermediate Staphylococcus aureus (hVISA) is 1.3% in published studies. Clinical associations include high-inoculum infections and glycopeptide failure, with hVISA infections associated with a 2.37-times ...
Van Hal, S.J., Paterson, D.L.
core   +1 more source

A review of antibiotic safety in pregnancy—2025 update

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 4, Page 227-237, April 2025.
Abstract Antibiotics constitute the majority of prescriptions for women during pregnancy. Common bacterial infections, including urinary tract infections, skin and soft tissue infections, and upper and lower respiratory tract infections, are expected in pregnancy, similar to the general public.
Johny Nguyen, Victoria Madonia, Christopher M. Bland, Kayla R. Stover, Lea S. Eiland, Julia Keating, Madeline Lemmon, P. Brandon Bookstaver, as part of the Southeastern Research Group Endeavor (SERGE‐45) research network   +8 more
wiley   +1 more source