Results 61 to 70 of about 3,123 (163)

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, Volume 22, Issue 16, 17 March 2026.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Evaluating the Effect of Therapeutic Antibiotics in Prosthetic Joint Infections Culturing: A Narrative Review

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims One of the important complications of knee and hip replacement arthroplasty is prosthetic joint infection (PJI), which is usually accompanied by negative culture that leads to severe consequences compared to positive ones. This study aims to evaluate the arbitrary use or mistreatment of antibiotics for therapeutic purposes ...
Moein Zangiabadian, Mehrdad Jafari Tadi, Fateme Yousefimoghaddam, Ali Zangiabadian, Amir Ghaffari Jolfayi   +4 more
wiley   +1 more source

Strategies to stabilize dalbavancin in aqueous solutions: Section 4—identification of heat degradation products in 2-hydroxypropyl-β-cyclodextrin and divalent metal ion solutions at pH 4.5 and 7.0

AAPS Open, 2023
Heat stress studies have been conducted in support of developing a heat-stable liquid solution of dalbavancin. The degradation products that form in heat-stressed buffered dalbavancin solutions have been identified, including the known major degradation ...
Sardar M. Jakaria, David E. Budil, James Murtagh   +2 more
doaj   +1 more source

Dalbavancin: a lipoglycopeptide antibacterial for gram-positive infections

, 2008
BACKGROUND: Dalbavancin is a lipoglycopeptide antibacterial agent with in vitro and in vivo activity against a number of Gram-positive organisms, including some with multidrug resistance.
Roecker, Andrew M., Pope, Scott D.
core   +1 more source

The hidden cost of dalbavancin: OPAT RN time required in coordination for persons who use drugs

Therapeutic Advances in Infectious Disease, 2023
Background: Serious infections in persons who use drugs (PWUD) are rising. Dalbavancin, due to its extended half-life, offers an alternative treatment for patients in whom standard of care antibiotics are not feasible or practical, allowing for reduced ...
Alyse H. Douglass, Heather Mayer, Kathleen Young, Monica K. Sikka, Luke Strnad, Jina Makadia, Ellie Sukerman, James S. Lewis, Amber C. Streifel   +8 more
doaj   +1 more source

Frontiers in the Management of Orthopaedic Periprosthetic Joint Infection

Journal of Orthopaedic Research, Volume 44, Issue 2, February 2026.
ABSTRACT Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty (TJA), one of the most frequently performed surgical procedures worldwide. Management of acute PJI commonly involves debridement, antibiotics, and implant retention (DAIR), though failure rates remain high due to antibiotic‐tolerant biofilms. Chronic
Michael F. Shannon, Victoria R. Wong, Samuelson E. Osifo, Timothy Edwards, Himanshu Rao, Jewelia Rempuszewski, Andrew J. Frear, Shaan Sadhwani, Neel B. Shah, Kenneth L. Urish   +9 more
wiley   +1 more source

Vancomycin‐Functionalized Nanodelivery Systems for Antibacterial Tissue Engineering Scaffolds

Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.
This review consolidates recent advancements in VAN nanoformulations, critically evaluating their design principles, release mechanisms, and efficacy profiles against resistant Gram‐positive pathogens. While promising in vitro and in vivo results have been demonstrated, the clinicaltranslation of these technologies necessitates further rigorous ...
Nima Beheshtizadeh, Mahsa Mohammadzadeh, Amir Abbas Seraji, Ali Pirsadeghi, Elham Zendedel, Maliheh Gharibshahian   +5 more
wiley   +1 more source

Dalbavancin to facilitate early discharge in the treatment of complex musculoskeletal infections: a multi-centre real-life application [PDF]

Journal of Bone and Joint Infection
Dalbavancin is a lipoglycopeptide with a half-life of 14 d, significantly reducing the need for daily antibiotic dosing. Although dalbavancin is approved for acute bacterial skin and skin structure infections, its off-label use in complex musculoskeletal
T. Azamgarhi, S. Warren, A. Scobie, N. Karunaharan, C. Perez-Sanchez, R. Houghton, S. Hassan, J. Lourtet-Hascoët, J. Lourtet-Hascoët, H. Kershaw, P. Sendi, K. Saeed, K. Saeed   +12 more
doaj   +1 more source

Prosthetic Mitral Valve Endocarditis due to Vagococcus fluvialis: A Case Report

Case Reports in Medicine, Volume 2026, Issue 1, 2026.
Infective endocarditis (IE) is an uncommon but life‐threatening disease, most frequently caused by Staphylococcus aureus, streptococci, and enterococci. Vagococcus fluvialis is a Gram‐stain positive coccus, phenotypically close to enterococci, and rarely identified in human infections due to diagnostic challenges.
Camille Le Guillou, Yvon Ruch, Florian Baquer, Pierre Boyer, Michel Kindo, Mircea Cristinar, Sebastien Brua, Paul Michel Mertes, Walid Oulehri, Amr A. Arafat   +9 more
wiley   +1 more source