Results 51 to 60 of about 4,279 (197)

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, Volume 22, Issue 16, 17 March 2026.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Long-Term Suppressive Therapeutic-Drug-Monitoring-Guided Dalbavancin Therapy for Cardiovascular Prosthetic Infections

Antibiotics, 2023
Dalbavancin represents a promising treatment for cardiovascular prosthetic infections due to its prolonged half-life, bactericidal activity, large spectrum of activity, and excellent biofilm penetration. However, the use of dalbavancin in this setting is
Altea Gallerani, Milo Gatti, Andrea Bedini, Stefania Casolari, Gabriella Orlando, Cinzia Puzzolante, Erica Franceschini, Marianna Menozzi, Antonella Santoro, Nicole Barp, Sara Volpi, Alessandra Soffritti, Federico Pea, Cristina Mussini, Marianna Meschiari   +14 more
doaj   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Dalbavancin as an alternative to traditional outpatient parenteral antimicrobial therapy for deep gram-positive infections – an observational, retrospective review

Therapeutic Advances in Infectious Disease
Background: Treatment of invasive gram-positive infections in complex patient populations is challenging. Dalbavancin, approved for skin and soft tissue infections, offers advantages in this setting due to its long half-life and infrequent dosing ...
Hongkai Bao, Rita Igwilo-Alaneme, Fnu Sonia, Kelsie Cowman, Mani Kahn, Priya Nori   +5 more
doaj   +1 more source

Investigation of linezolid resistance in staphylococci and enterococci [PDF]

, 2016
The objective of this study was to investigate an apparent increase in linezolid-nonsusceptible staphylococci and enterococci following a laboratory change in antimicrobial susceptibility testing from disk diffusion to an automated susceptibility testing
Alspaugh, Debbie, Burnham, Carey-Ann D, Doern, Christopher D, Gallegos, Michael, Park, Jason Y   +4 more
core   +2 more sources

Evaluating the Effect of Therapeutic Antibiotics in Prosthetic Joint Infections Culturing: A Narrative Review

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims One of the important complications of knee and hip replacement arthroplasty is prosthetic joint infection (PJI), which is usually accompanied by negative culture that leads to severe consequences compared to positive ones. This study aims to evaluate the arbitrary use or mistreatment of antibiotics for therapeutic purposes ...
Moein Zangiabadian, Mehrdad Jafari Tadi, Fateme Yousefimoghaddam, Ali Zangiabadian, Amir Ghaffari Jolfayi   +4 more
wiley   +1 more source

Experience of Real-Life Use of Dalbavancin as an Off-Label Treatment of Complicated Infectious Diseases in a Tertiary Care Hospital [PDF]

, 2022
Dalbavancin is a lipoglycopeptide indicated for the treatment of acute bacterial skin and skin structure infections. The aim of this study is to describe the cases in which dalbavancin has been used as an off-label use for the treatment of infections by ...
Allende, María Ángeles, Arenere, Mercedes, Bonaga, Beatriz, Fresquet, Raquel, Frutos Pérez-Surio, Alberto, Gracia, Raquel, Pascual, Oihana, Salvador, María del Tránsito, Vinuesa, José Manuel   +8 more
core   +2 more sources

Frontiers in the Management of Orthopaedic Periprosthetic Joint Infection

Journal of Orthopaedic Research, Volume 44, Issue 2, February 2026.
ABSTRACT Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty (TJA), one of the most frequently performed surgical procedures worldwide. Management of acute PJI commonly involves debridement, antibiotics, and implant retention (DAIR), though failure rates remain high due to antibiotic‐tolerant biofilms. Chronic
Michael F. Shannon, Victoria R. Wong, Samuelson E. Osifo, Timothy Edwards, Himanshu Rao, Jewelia Rempuszewski, Andrew J. Frear, Shaan Sadhwani, Neel B. Shah, Kenneth L. Urish   +9 more
wiley   +1 more source

Dalbavancin for Successful Treatment of Infective Endocarditis Caused by Enterococcus faecalis

European Journal of Case Reports in Internal Medicine, 2023
Infective endocarditis is a relatively uncommon infection that requires a high index of suspicion, which can sometimes delay its diagnosis. It requires several weeks of intravenous antibiotics, which traditionally requires long hospital stays ...
Francisco Javier Teigell Muñoz, María Mateos-González, Elsa Bernal-Hertfelder, Ana Sánchez de Torre, María García-Ferrón, Carmen de Cáceres Velasco, Coralia Bueno Muiño   +6 more
doaj   +1 more source

In vitro and in vivo antibacterial effect of NZ2114 against Streptococcus suis type 2 infection in mice peritonitis models [PDF]

, 2017
NZ2114 is a promising candidate for therapeutic application owing to potent activity to gram-positive bacterium such as Streptococcus pneumoniae and Staphylococcus aureus.
Da Teng, Jian Jiao, Jianhua Wang, Na Yang, Ruoyu Mao, Xiao Wang, Xingjun Feng, Xiumin Wang, Ya Hao   +8 more
core   +1 more source