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Teicoplanin—A New Use for an Old Drug in the COVID-19 Era?

Pharmaceuticals, 2021
Teicoplanin is an antibiotic that has been actively used in medical practice since 1986 to treat serious Gram-positive bacterial infections. Due to its efficiency and low cytotoxicity, teicoplanin has also been used for patients with complications ...
Vladimir Vimberg
exaly   +3 more sources

Population Pharmacokinetics and Model-Informed Dose Optimization of Teicoplanin in Adults with Hematological Malignancies [PDF]

Pharmaceutics
Background: Teicoplanin is widely used for the empirical and targeted treatment of febrile neutropenia in patients with hematological malignancies. However, the pathophysiological alterations typical of this population may substantially affect drug ...
María García-Hervalejo, José Germán Sánchez-Hernández, Irene Conde-González, Alejandro Avendaño Pita, María José Otero   +4 more
doaj   +2 more sources

Incidence of teicoplanin adverse drug reactions among patients with vancomycin-associated adverse drug reactions and its risk factors [PDF]

The Korean Journal of Internal Medicine, 2020
Background/Aims Teicoplanin can be used as an alternative to vancomycin when treating beta-lactam-resistant gram-positive bacterial infections. Both vancomycin and teicoplanin are associated with relatively high rates of adverse drug reactions (ADRs ...
Byung-Keun Kim, Jung-Hyun Kim, Kyoung-Hee Sohn, Ju-Young Kim, Yoon-Seok Chang, Sae-Hoon Kim   +5 more
doaj   +1 more source

Teicoplanin-Resistant Coagulase-Negative Staphylococci: Do the Current Susceptibility Testing Methods Reliably Detect This Elusive Phenotype?

Antibiotics, 2023
Coagulase-negative staphylococci (CoNS), members of the skin commensal microbiota, are increasingly associated with local or systemic infections due to a shift in patient populations in recent decades.
Adriana D. Balasiu, Colin R. MacKenzie
doaj   +1 more source

Comparison of Different Phenotypic Methods Including E-test, Cefoxitin and Oxacillin Disk Diffusion for Detection of Methicillin Resistant Staphylococcus aureus [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Methicillin-Resistant Staphylococcus aureus (MRSA) has spread throughout the world as a hospital and communityacquired illness. Although, a variety of strategies have been employed, laboratory identification of MRSA remains a difficulty.
Geeta Gupta, Pradeep Kumar
doaj   +1 more source

Increased incidence of teicoplanin-non-susceptible Staphylococcus epidermidis strains: a 6-year retrospective study

Scientific Reports, 2023
Glycopeptide antibiotics (vancomycin and teicoplanin) are usually used for the treatment of Staphylococcus epidermidis infections owing to their increased oxacillin resistance. However, S.
Subin Kim, Jae-Phil Choi, Dong Hyun Oh, Mi Young Ahn, Eunmi Yang   +4 more
doaj   +1 more source

Prospective study of irrational prescription of teicoplanin in a large academic hospital: A dilemma of antimicrobial resistance

Journal of Research in Pharmacy Practice, 2020
Objective: Teicoplanin is an antibiotic used to treat severe Gram-positive infections, especially those caused by methicillin-resistant Staphylococcus aureus(MRSA).
Masoud Hajialigol, Shadi Farsaei, Kiana Shirani   +2 more
doaj   +1 more source

Efficacy of teicoplanin in bloodstream infections caused by Enterococcus faecium: posthoc analysis of a nationwide surveillance

International Journal of Infectious Diseases, 2022
Objectives: Vancomycin and teicoplanin are glycopeptides with activity against Enterococcus faecium. However, studies on the clinical efficacy of teicoplanin are limited.
Soyoung Ha, Kyungmin Huh, Doo Ryeon Chung, Jae-Hoon Ko, Sun Young Cho, Hee Jae Huh, Nam Yong Lee, Cheol-In Kang, Kyong Ran Peck, Jae-Hoon Song   +9 more
doaj   +1 more source

Therapeutic drug monitoring of the teicoplanin trough level after the loading doses in patients receiving venoarterial extracorporeal membrane oxygenation

Journal of the Formosan Medical Association, 2020
Background: The optimal loading dose of teicoplanin in patients receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO) has never been determined by therapeutic drug monitoring. This study investigated the appropriateness of proposed loading
Guan-Jhou Chen, Shu-Wen Lin, I-Lin Tsai, Ching-Hua Kuo, Jann-Tay Wang, Szu-Min Hsieh   +5 more
doaj   +1 more source

Natural Apocarotenoids and Their Synthetic Glycopeptide Conjugates Inhibit SARS-CoV-2 Replication

Pharmaceuticals, 2021
The protracted global COVID-19 pandemic urges the development of new drugs against the causative agent SARS-CoV-2. The clinically used glycopeptide antibiotic, teicoplanin, emerged as a potential antiviral, and its efficacy was improved with lipophilic ...
Ilona Bereczki, Henrietta Papp, Anett Kuczmog, Mónika Madai, Veronika Nagy, Attila Agócs, Gyula Batta, Márton Milánkovits, Eszter Ostorházi, Ana Mitrović, Janko Kos, Áron Zsigmond, István Hajdú, Zsolt Lőrincz, Dávid Bajusz, György Miklós Keserű, Jan Hodek, Jan Weber, Ferenc Jakab, Pál Herczegh, Anikó Borbás   +20 more
doaj   +1 more source