Results 31 to 40 of about 6,643,331 (384)

Assessment of damage in vasculitis: expert ratings of damage [PDF]

Rheumatology, 2009
Current measures of damage in vasculitis do not account for the possibility that some forms of damage may exert greater impact than others. As part of an international effort to revise how damage is quantified in vasculitis clinical research, an exercise was performed to measure expert ratings of damage items.Members of the Vasculitis Clinical Research
Seo, P, Jayne, D, Luqmani, R, Merkel, P
openaire   +3 more sources

Bone Marrow CD133 Stem Cells Ameliorate Visual Dysfunction in Streptozotocin-induced Diabetic Mice with Early Diabetic Retinopathy

Cell Transplantation, 2018
Diabetic retinopathy (DR), one of the leading causes of vision loss worldwide, is characterized by neurovascular disorders. Emerging evidence has demonstrated retinal neurodegeneration in the early pathogenesis of DR, and no treatment has been developed ...
Liyuan Rong, Xianliang Gu, Jing Xie, Yuxiao Zeng, Qiyou Li, Siyu Chen, Ting Zou, Langyue Xue, Haiwei Xu, Zheng Qin Yin   +9 more
doaj   +1 more source

Automation of the cytokinesis-block micronucleus cytome assay by laser scanning cytometry and its potential application in radiation biodosimetry

BioTechniques, 2014
Here we describe the adaptation of laser scanning cytometry (LSC) to measure micronuclei (MN) automatically in lymphocytes. MN frequencies were determined in irradiated human lymphocytes using the cytokinesis-block technique, and the results from LSC ...
Maxime François, Kevin Hochstenbach, Wayne Leifert, Michael Felix Fenech   +3 more
doaj   +1 more source

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.

Cell, 1998
We report here that BID, a BH3 domain-containing proapoptotic Bcl2 family member, is a specific proximal substrate of Casp8 in the Fas apoptotic signaling pathway.
Honglin Li, Hong Zhu, Chi-jie Xu, Junying Yuan   +3 more
semanticscholar   +1 more source

The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins

Nature Communications, 2016
Werner syndrome is a progeroid disease characterised by genetic instability due to mutations to the WRN helicase/exonuclease. Here the authors define a novel Ku binding motif (KBM) and show that two such motifs facilitate the involvement of WRN in DNA ...
Gabrielle J. Grundy, Stuart L. Rulten, Raquel Arribas-Bosacoma, Kathryn Davidson, Zuzanna Kozik, Antony W. Oliver, Laurence H. Pearl, Keith W. Caldecott   +7 more
doaj   +1 more source

Olfactory Ensheathing Cells Inhibit Gliosis in Retinal Degeneration by Downregulation of the Müller Cell Notch Signaling Pathway

Cell Transplantation, 2017
Retinal regeneration and self-repair, whether in response to injury or degenerative disease, are severely impeded by glial scar formation by Müller cells (specialized retinal macroglia). We have previously demonstrated that the activation of Müller cells
Jing Xie, Shujia Huo, Yijian Li, Jiaman Dai, Haiwei Xu, Zheng Qin Yin   +5 more
doaj   +1 more source

Liver stiffness and arterial stiffness/abnormal central hemodynamics in the early stage of heart failure

International Journal of Cardiology: Heart & Vasculature, 2018
Background: It remains to be clarified whether liver stiffness is a direct risk factor for heart failure (HF) or whether its association with HF is mediated by vascular damage.
Yoichi Iwasaki, Hirofumi Tomiyama, Kazuki Shiina, Chisa Matsumoto, Kazutaka Kimura, Masatsune Fujii, Yoshifumi Takata, Akira Yamashina, Taishiro Chikamori   +8 more
doaj   +1 more source

DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy

Signal Transduction and Targeted Therapy, 2021
Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of cancers.
Ruixue Huang, P. Zhou
semanticscholar   +1 more source

Genetic and physical interactions between Polη and Rev1 in response to UV-induced DNA damage in mammalian cells

Scientific Reports, 2021
In response to UV irradiation, translesion DNA synthesis (TLS) utilizes specialized DNA polymerases to bypass replication-blocking lesions. In a well-established polymerase switch model, Polη is thought to be a preferred TLS polymerase to insert correct ...
Tonghui Bi, Xiaohong Niu, Chunping Qin, Wei Xiao   +3 more
doaj   +1 more source

The central role of DNA damage in the ageing process

Nature, 2021
Ageing is a complex, multifaceted process leading to widespread functional decline that affects every organ and tissue, but it remains unknown whether ageing has a unifying causal mechanism or is grounded in multiple sources.
B. Schumacher, J. Pothof, J. Vijg, J. Hoeijmakers   +3 more
semanticscholar   +1 more source