Results 11 to 20 of about 6,683,927 (310)

Replication dynamics of recombination-dependent replication forks

Nature Communications, 2021
Replication forks that are stalled at obstacles on the DNA template can be restarted by homologous recombination. Here, the authors show replication dynamics during homologous recombination-dependent replication fork restart by combining polymerase usage
Karel Naiman, Eduard Campillo-Funollet, Adam T. Watson, Alice Budden, Izumi Miyabe, Antony M. Carr   +5 more
doaj   +1 more source

HspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells

Cell Death and Disease, 2022
The Hsp70-binding protein 1 (HspBP1) belongs to a family of co-chaperones that regulate Hsp70 activity and whose biological significance is not well understood.
Cha Kyung Youn, Jung-Hee Lee, Gurusamy Hariharasudhan, Hong Beum Kim, Jeeho Kim, Sumi Lee, Sung-Chul Lim, Sang-Pil Yoon, Sang-Gon Park, In-Youb Chang, Ho Jin You   +10 more
doaj   +1 more source

Valvular damage

Journal of Cardiovascular Echography, 2020
Valvular heart diseases (VHD) may be observed in patients with cancer for several reasons, including preexisting valve lesions, radiotherapy, infective endocarditis, and secondary to the left ventricle dysfunction. The incidence of VHD is especially in younger survivors treated with thoracic radiation therapy for certain malignancies, such as Hodgkin's
Ines Paola Monte, Matteo Cameli, Valentina Losi, Fiorella Privitera, Rodolfo Citro   +4 more
openaire   +4 more sources

Schizosaccharomyces pombe Rtf2 is important for replication fork barrier activity of RTS1 via splicing of Rtf1

eLife, 2023
Arrested replication forks, when restarted by homologous recombination, result in error-prone DNA syntheses and non-allelic homologous recombination. Fission yeast RTS1 is a model fork barrier used to probe mechanisms of recombination-dependent restart ...
Alice M Budden, Murat Eravci, Adam T Watson, Eduard Campillo-Funollet, Antony W Oliver, Karel Naiman, Antony M Carr   +6 more
doaj   +1 more source

CRISPR-Associated Primase-Polymerases are implicated in prokaryotic CRISPR-Cas adaptation

Nature Communications, 2021
CAPPs are putative Primase-Polymerases associated with CRISPR-Cas operons. Here, the authors show CAPPs genetic and physical association with Cas1 and Cas2, their capacity to function as DNA-dependent DNA primases and DNA polymerases, and that Cas1-Cas2 ...
Katerina Zabrady, Matej Zabrady, Peter Kolesar, Arthur W. H. Li, Aidan J. Doherty   +4 more
doaj   +1 more source

Inhibition of MRN activity by a telomere protein motif

Nature Communications, 2021
Telomeres suppress the DNA damage response at chromosome ends. Here the authors show that in budding yeast the activity of the MRX complex in DNA repair and DNA damage signaling is inhibited by telomeric protein Rif2 via a short motif at the N-terminus.
Freddy Khayat, Elda Cannavo, Majedh Alshmery, William R. Foster, Charly Chahwan, Martino Maddalena, Christopher Smith, Antony W. Oliver, Adam T. Watson, Antony M. Carr, Petr Cejka, Alessandro Bianchi   +11 more
doaj   +1 more source

Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo

eLife, 2021
The essential Smc5/6 complex is required in response to replication stress and is best known for ensuring the fidelity of homologous recombination. Using single-molecule tracking in live fission yeast to investigate Smc5/6 chromatin association, we show ...
Thomas J Etheridge, Desiree Villahermosa, Eduard Campillo-Funollet, Alex David Herbert, Anja Irmisch, Adam T Watson, Hung Q Dang, Mark A Osborne, Antony W Oliver, Antony M Carr, Johanne M Murray   +10 more
doaj   +1 more source

On Damage Spreading Transitions [PDF]

, 1995
We study the damage spreading transition in a generic one-dimensional stochastic cellular automata with two inputs (Domany-Kinzel model) Using an original formalism for the description of the microscopic dynamics of the model, we are able to show ...
E. Domany, F. Bagnoli, F. Bagnoli, F. Bagnoli, Franco Bagnoli, G. A. Kohring, G. F. Zabende, H. A. Gutowitz, H. K. Jannsen, H. Rieger, M. L. Martins, P. Grassberger, P. Grassberger, R. Dickman, S. Kauffman, T. Tomé, W. Kinzel   +16 more
core   +2 more sources

Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle [PDF]

, 2014
Inflammation is the ultimate response to the constant challenges of the immune system by microbes, irritants or injury. The inflammatory cascade initiates with the recognition of microorganism-derived pathogen associated molecular patterns (PAMPs) and ...
Abe, Alexeyev, Andersson, Andersson, Ba, Babior, Bartoloni, Berger, Blyth, Brill, Brinkmann, Cadet, Collins, Cooke, Csanád Z. Bachrati, David, Ding, Dostert, Ermakov, Ermakov, Ferguson, Fuchs, Gahan, Gedik, Gehrke, Hajizadeh, Halle, Hiramoto, Huang, Huang, Huang, Huttunen, Ishikawa, Ivana, Ivanov, Jahr, Jia, Kang, Kanneganti, Kazak, Klebanoff, Knaapen, Kondo, Kostyuk, Kostyuk, Krieg, Kuechle, Lane, Lange, Latz, Li, Malins, Mariathasan, Munoz-Gamez, Nakahira, Oka, Pacher, Parvatiyar, Pasheva, Pinti, Polk, Rathinam, Saitoh, Saxena, Scaffidi, Schroder, Shimada, Shokolenko, Sun, Suter, Suzuki, Swindall, Tadie, Taguchi, Takeda, Takeda, Tang, Tang, Thomson, Timea Pálmai-Pallag, Unterholzner, Urbonaviciute, Venereau, Volcic, Weinberg, Weiss, Wilson, Wu, Yan, Yang, Yoshida, Yoshihara, Yotsumoto, You, Yousefi, Zhang, Zhang, Zhang, Zhang, Zhang, Zhou   +100 more
core   +1 more source

Charging damage in floating metal-insulator-metal capacitors [PDF]

, 2002
In this paper, charging induced damage (CID) to metal-insulator-metal capacitors (MIMC) is reported. The damage is caused by the build up of a voltage potential difference between the two plates of the capacitor.
Ackaert, Jan, Coppens, P., De Backer, E., Wang, Zhichun   +3 more
core   +2 more sources