Results 21 to 30 of about 6,643,331 (384)
Pyroptosis-induced inflammation and tissue damage
Seminars in Immunology, 2023 Pyroptosis is a programmed necrotic cell death executed by gasdermins, a family of pore-forming proteins. The cleavage of gasdermins by specific proteases enables their pore-forming activity. The activation of the prototype member of the gasdermin family,
Swathy O. Vasudevan +2 more
semanticscholar +1 more source
Principal component analysis and perturbation theory–based robust damage detection of multifunctional aircraft structure [PDF]
, 2013 A fundamental problem in structural damage detection is to define an efficient feature to calculate a damage index. Furthermore, due to perturbations from various sources, we also need to define a rigorous threshold whose overtaking indicates the ...
HAJRYA, Rafik, MECHBAL, Nazih
core +1 more source
A Review of Vibration-Based Damage Detection in Civil Structures: From Traditional Methods to Machine Learning and Deep Learning Applications [PDF]
arXiv.org, 2020 Monitoring structural damage is extremely important for sustaining and preserving the service life of civil structures. While successful monitoring provides resolute and staunch information on the health, serviceability, integrity and safety of ...
Onur Avcı +5 more
semanticscholar +1 more source
The DNA Damage Response: Making it safe to play with knives
Molecules and Cells, 2010 Damage to our genetic material is an ongoing threat to both our ability to faithfully transmit genetic information to our offspring as well as our own survival. To respond to these threats, eukaryotes have evolved the DNA Damage Response (DDR).
Alberto Ciccia, S. Elledge
semanticscholar +1 more source
The DNA-damage response in human biology and disease
Nature, 2009 The prime objective for every life form is to deliver its genetic material, intact and unchanged, to the next generation. This must be achieved despite constant assaults by endogenous and environmental agents on the DNA.
S. Jackson, J. Bartek
semanticscholar +1 more source
A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome
Nature Communications, 2019 Topoisomerase 2 (Top2) is known to resolve DNA topological stress through double strand breaks (DSBs), yet Top2 inhibition has been reported to result in a significant amount of single-strand breaks (SSBs).
William H. Gittens +5 more
doaj +1 more source
Nature Communications, 2019 The kinase PLK1 has important roles during cell division, including mitotic entry and bipolar spindle formation. Here, the authors show that PLK1 also functions in centromere protection, with loss leading to DNA unwinding by Bloom’s syndrome helicase and
Owen Addis Jones +4 more
doaj +1 more source
, 2012 Reactive oxygen species (ROS) are produced as a normal product of plant cellular metabolism. Various environmental stresses lead to excessive production of ROS causing progressive oxidative damage and ultimately cell death.
Pallavi Sharma +3 more
semanticscholar +1 more source
Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective
Biochemical Pharmacology, 2020 Graphical ...
Samik Bindu +2 more
semanticscholar +1 more source
ALVEOLAR DAMAGE: EPITHELIAL DAMAGE AND ENDOTHELIAL DAMAGE
Journal of Toxicologic Pathology, 1989 The alveolar damage produced by a variety of toxic agents, whether air-borne or blood-borne, progresses to a sequence of nonspecific changes histologically regarded as diffuse alveolar damage. Ultrastructurally, their alveolar damage can be divided into epithelial and endothelial type according to their target cells. The epithelial and endothelial type
Ogata, Takesaburo +4 more
openaire +2 more sources