Results 21 to 30 of about 4,219,800 (278)
A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome
Nature Communications, 2019 Topoisomerase 2 (Top2) is known to resolve DNA topological stress through double strand breaks (DSBs), yet Top2 inhibition has been reported to result in a significant amount of single-strand breaks (SSBs).
William H. Gittens +5 more
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Nature Communications, 2019 The kinase PLK1 has important roles during cell division, including mitotic entry and bipolar spindle formation. Here, the authors show that PLK1 also functions in centromere protection, with loss leading to DNA unwinding by Bloom’s syndrome helicase and
Owen Addis Jones +4 more
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BioTechniques, 2014 Here we describe the adaptation of laser scanning cytometry (LSC) to measure micronuclei (MN) automatically in lymphocytes. MN frequencies were determined in irradiated human lymphocytes using the cytokinesis-block technique, and the results from LSC ...
Maxime François +3 more
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ALVEOLAR DAMAGE: EPITHELIAL DAMAGE AND ENDOTHELIAL DAMAGE
Journal of Toxicologic Pathology, 1989 The alveolar damage produced by a variety of toxic agents, whether air-borne or blood-borne, progresses to a sequence of nonspecific changes histologically regarded as diffuse alveolar damage. Ultrastructurally, their alveolar damage can be divided into epithelial and endothelial type according to their target cells. The epithelial and endothelial type
Ogata, Takesaburo +4 more
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Assessment of damage in vasculitis: expert ratings of damage [PDF]
Rheumatology, 2009 Current measures of damage in vasculitis do not account for the possibility that some forms of damage may exert greater impact than others. As part of an international effort to revise how damage is quantified in vasculitis clinical research, an exercise was performed to measure expert ratings of damage items.Members of the Vasculitis Clinical Research
Seo, P, Jayne, D, Luqmani, R, Merkel, P
openaire +3 more sources
Cell Transplantation, 2018 Diabetic retinopathy (DR), one of the leading causes of vision loss worldwide, is characterized by neurovascular disorders. Emerging evidence has demonstrated retinal neurodegeneration in the early pathogenesis of DR, and no treatment has been developed ...
Liyuan Rong +9 more
doaj +1 more source
Nature Communications, 2016 Werner syndrome is a progeroid disease characterised by genetic instability due to mutations to the WRN helicase/exonuclease. Here the authors define a novel Ku binding motif (KBM) and show that two such motifs facilitate the involvement of WRN in DNA ...
Gabrielle J. Grundy +7 more
doaj +1 more source
Cell Transplantation, 2017 Retinal regeneration and self-repair, whether in response to injury or degenerative disease, are severely impeded by glial scar formation by Müller cells (specialized retinal macroglia). We have previously demonstrated that the activation of Müller cells
Jing Xie +5 more
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International Journal of Cardiology: Heart & Vasculature, 2018 Background: It remains to be clarified whether liver stiffness is a direct risk factor for heart failure (HF) or whether its association with HF is mediated by vascular damage.
Yoichi Iwasaki +8 more
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The damage in negotiating damages
, 2023 Abstract This chapter advances a new analysis of One Step negotiating damages, urging that the claim underpinning these awards is a claim for restitution for unjust enrichment, not a claim for damages in contract. Moreover, this unjust enrichment claim is for the enrichment derived by D from its use of C’s property without C’s consent ...
openaire +3 more sources