Results 41 to 50 of about 58,757 (315)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Anisotropic Elastoplastic Damage Mechanics Method to Predict Fatigue Life of the Structure
Advances in Materials Science and Engineering, 2016 New damage mechanics method is proposed to predict the low-cycle fatigue life of metallic structures under multiaxial loading. The microstructure mechanical model is proposed to simulate anisotropic elastoplastic damage evolution.
Hualiang Wan, Qizhi Wang, Zheng Zhang
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
A Generalized Hypothesis of Elastic Energy Equivalence in Continuum Damage Mechanics
Engineering Transactions, 2017 A new generalized hypothesis of elastic energy equivalence is proposed. The proposed generalized hypothesis is inclusive of all the existing different hypotheses of equivalence in continuum damage mechanics and all are obtained as special cases ...
George Z. VOYIADJIS, Peter I. KATTAN
doaj +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Acta Scientiarum: Technology, 2009 In this work, non-linear analyses of reinforced concrete plates are performed by using a BEM formulation, based on Kirchhoff’s theory, which has already proved to be a robust technique to deal with plate problems.
Gabriela Rezende Fernandes +2 more
doaj +1 more source
Mechanics and failure analysis of stitched sandwich structures damaged by the impact of various energies [PDF]
, 2023 Amina Assouli
openalex +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Zhongguo Jianchuan YanjiuLarge ships and submarines are the main equipment and mobile platforms supporting three-dimensional naval space operations. However, with the increasing damage power and strike accuracy of warheads, plus the diversity of destroying elements, their living
Ying LI +13 more
doaj +1 more source