Results 251 to 260 of about 1,333,549 (315)

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

The damage mechanism in copper studied using in situ TEM nanoindentation. [PDF]

Nanoscale Adv
Wang D, Zhang Z, Liu D, Deng X, Shi C, Gu Y, Liu X, Liu X, Wen W.   +8 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Determination of Material and Fracture Properties of a Case-Hardened Planet Gear and Its Homogenisation Method to Obtain the Damage Mechanism Caused by Fragment Ingestion. [PDF]

Materials (Basel)
Jeßberger J, Fischer C, Rinderknecht S.
europepmc   +1 more source

Understanding the role of a polymorphic MUTYH variant in oxidative damage repair

, 2011
Eleonora Turco, Sara Molatore, Filomena Mazzei, Maria Teresa Russo, Paolo Degan, Margherita Bignami, RANZANI, GUGLIELMINA, Anna Minoprio   +7 more
core  

Critical review of the creep damage constitutive equations for high Cr steel

Wang, Xue Z., Xu, Qiang
core  

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Mechanisms of kidney damage

Urologiia, 2019
The results of recent studies on the mechanisms of kidney damage are presented in the review of literature. The role of the immune system in the occurrence, development and outcome of damage to the epithelium of the renal tubules, as well as molecular, genetic and metabolic changes which determine the extent and consequences of renal trauma are ...
A I, Tarasenko, A V, Alekseev, S Yu, Maksimova   +2 more
openaire   +2 more sources

Mechanisms of Liver Damage

Seminars in Liver Disease, 1996
The liver is implicated in many processes, and its failure induces severe consequences for metabolism, immune response, detoxification and antimicrobial defenses. The mechanisms involved in liver injury are complex and interactive, and can be artificially separated as chemical and immune injuries.
M R, Losser, D, Payen
openaire   +2 more sources