Results 41 to 50 of about 875,259 (309)

Corrosion-Induced Damage and Residual Strength of WC-Co,Ni Cemented Carbides: Influence of Microstructure and Corrosion Medium

open access: yesMetals, 2019
The corrosion behavior of cemented carbides with binders of different chemical nature (Co and Ni) and carbides with distinct mean grain size (ultrafine and coarse) was studied. The investigation also included corrosion media (acidic and neutral solutions
Yafeng Zheng   +4 more
doaj   +1 more source

Chemical investigation of light induced DNA bipyrimidine damage and repair [PDF]

open access: yes, 2011
In all organisms, genetic information is stored in DNA and RNA. Both of these macromolecules are damaged by many exogenous and endogenous events, with UV irradiation being one of the major sources of damage.
Carell, Thomas   +2 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Among-population variation in tolerance to larval herbivory by Anthocharis cardamines in the polyploid herb Cardamine pratensis. [PDF]

open access: yesPLoS ONE, 2014
Plants have two principal defense mechanisms to decrease fitness losses to herbivory: tolerance, the ability to compensate fitness after damage, and resistance, the ability to avoid damage.
Malin A E König   +3 more
doaj   +1 more source

Ischemic Tolerance—A Way to Reduce the Extent of Ischemia–Reperfusion Damage

open access: yesCells, 2023
Individual tissues have significantly different resistance to ischemia–reperfusion damage. There is still no adequate treatment for the consequences of ischemia–reperfusion damage.
Rastislav Burda   +2 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Discussions on some problems of full-scale aircraft fatigue test

open access: yesHangkong gongcheng jinzhan
Full-scale aircraft fatigue test is a large, complex and long-lasting ground verification test required by the specification to sustain aircraft structural integrity program and meet airworthiness requirements.
ZHANG Lixin
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

AGING AIRCRAFT STRUCTURES LIFE TIME

open access: yesНаучный вестник МГТУ ГА, 2017
Analysis of US and Russia Regulations on fatigue and damage tolerance of transport aircraft structures is given. The methods to provide the safe operation of aging aircraft in Russia are presented for cases of multiple site damages, corrosion and ...
B. G. Nesterenko, G. I. Nesterenko
doaj  

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