Results 61 to 70 of about 875,259 (309)

Towards a methodology for the practical applications of the EIFS (Equivalent Initial Flaw Size) concept

Latin American Journal of Solids and Structures
This work intends to introduce a probabilistic approach for the crack propagation analysis. It presents a methodology that is based on the distribution of the initial flaw size a0.
Juliana Diniz Mattos, Carlos Eduardo Chaves   +1 more
doaj   +1 more source

Energy-absorbing wood composite for improved damage tolerance inspired by mollusc shells

Materials Research Express, 2020
The crossed lamellar structure (CLS) found in mollusc shells is an excellent example for nature’s ability to form complex hierarchical microstructures with a remarkable balance between strength and toughness.
Maximilian Pramreiter, Martin Rohner, Cedou Kumpenza, Bernhard Ungerer, Alexander Stadlmann, Jozef Keckes, Ulrich Müller   +6 more
doaj   +1 more source

Development of methologies to study the damage tolerance of aeronautical and aerospace composite structures [PDF]

, 2008
Mechanics of Advanced Materials research group (Department of Continuum Mechanics and Structural Analysis) of the University Carlos III of Madrid (Spain) offers their experience in the analysis and modelization of high and low velocity impact behaviour ...
Barbero Pozuelo, Enrique, Sánchez Sáez, Sonia   +1 more
core   +1 more source

RanBP2-Mediated SUMOylation Promotes Human DNA Polymerase Lambda Nuclear Localization and DNA Repair [PDF]

, 2020
Cellular DNA is under constant attack by a wide variety of agents, both endogenous and exogenous. To counteract DNA damage, human cells have a large collection of DNA repair factors. Among them, DNA polymerase lambda (Polλ) stands out for its versatility,
Cortés Ledesma, Felipe, García Domínguez, Mario, Herrero Ruiz, Andrés M., Moreno Oñate, Marta, Ruiz Pérez, José Francisco   +4 more
core   +1 more source

Mechanism of DNA damage tolerance

World Journal of Biological Chemistry, 2015
DNA damage may compromise genome integrity and lead to cell death. Cells have evolved a variety of processes to respond to DNA damage including damage repair and tolerance mechanisms, as well as damage checkpoints. The DNA damage tolerance (DDT) pathway promotes the bypass of single-stranded DNA lesions encountered by DNA polymerases during DNA ...
openaire   +2 more sources

Damage resistance and damage tolerance of hybrid carbon-glass laminates [PDF]

Composites Part A: Applied Science and Manufacturing, 2011
AbstractThe influence of impact energy and stacking sequence on the damage resistance and Compression After Impact (CAI) strength of Carbon and Glass Fibre Reinforced Plastic (CFRP and GFRP respectively) hybrid laminates is investigated. CAI tests demonstrate that, in comparison to fully CFRP laminates, hybrid laminates show increases in structural ...
Rhead, Andrew, Hua, Shi, Butler, Richard
openaire   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Fatigue, Fracture, and Damage Tolerance of Ultrahigh-Strength Martensitic Tendon-Rods for Structural Engineering

Applied Sciences
The paper addresses the fatigue resistance, fracture behavior, and damage tolerance of a new type of ultrahigh-strength bar for prestressing concrete made of a low-alloy lath martensitic steel. The fracture tests show that the bar steel has a medium-high
Patricia Santos, Mihaela Iordachescu, Andrés Valiente, Elena Scutelnicu   +3 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source