Results 71 to 80 of about 670,121 (313)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Continuum Damage-Healing Mechanics with Introduction to New Healing Variables
, 2012 In this study, damage and healing mechanisms are discussed in detail with special emphasis given on two new healing variables. They are introduced in terms of healing variable based on area and healing variable based on elastic stiffness.
George Voyiadjis
core +1 more source
A thermodynamically consistent derivation of a frictional-damage cohesive-zone model with different mode i and mode II fracture energies [PDF]
, 2015 The present paper deals with the derivation of an interface model characterized by macroscopic fracture energies which are different in modes I and II, the macroscopic fracture energy being the total energy dissipated per unit of fracture area.
Serpieri, R +3 more
core +1 more source
Uniaxial accelerated creep constitutive model of rock considering damage and hardening
Shuiwen dizhi gongcheng dizhiIn view of the lack of understanding and description of nonlinear characteristics and accelerated creep deformation law in current rock creep research, and the difficulty of existing models to fully reflect the coupling effect of damage and hardening in ...
Yingbo LI, Wenbo LIU, Shuguang ZHANG
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
On an isotropic damage mechanics model for ductile materials
, 2022 S.325-346A new model for combined elastoplasticity and damage is proposed. The model is based on the maximum dissipation principle and implements a strong coupling between plasticity and damage.
Hesebeck, O.
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Meitan xuebaoThe work aimed to study the damage and acoustic emission (AE) characteristics of sandstone under the cyclic disturbance stress during underground engineering excavation.
Chaotao FAN +6 more
doaj +1 more source
Reaction Time Variability in Epileptic and Brain-Damaged Patients
Cortex, 1977 Median reaction times and intra-individual variability were studied in epileptic (N = 63), brain-damaged (non-epileptic) (N = 25) and control patients (N = 25) using a six and one half minute visual, continuous reaction time task. Epileptic and brain-damaged groups were significantly slower than control patients on median reaction times at the 10th ...
P, Bruhn, O A, Parsons
openaire +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source