Results 81 to 90 of about 670,121 (313)

Application of damage mechanics in percussive drilling modelling

open access: yes, 2005
A stationary-periodic quasi-static model of rock percussive deep drilling is introduced. First, an auxiliary problem of stationary indentation of a rigid indentor is considered.
Mikhailov, SE   +3 more
core  

A mission synthesis algorithm for fatigue damage analysis

open access: yes, 2004
This paper presents a signal processing based algorithm, the Mildly Nonstationary Mission Synthesis (MNMS), which produces a short mission signal from long records of experimental data.
Abdullah, S, Giacomin, J, Yates, J R
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Deformation Characteristics and Energy Evolution Rules of Siltstone under Stepwise Cyclic Loading and Unloading

open access: yesBuildings
Uniaxial step cyclic loading and unloading tests on siltstone were conducted to investigate the mechanisms and evolution characteristics of rock deformation, including elastic, viscoelastic, and plastic aspects.
Shengjun Miao   +5 more
doaj   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Experimental study and application of hydraulic fracturing in underlying coal seam

open access: yesMeitan kexue jishu
The coalbed methane resource under goaf is rich, but has not been effectively developed for a long time. Hydraulic fracturing technology stands as an effective means to augment coalbed methane recovery.
Yongxin LU   +7 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Modelling of Damage in Orthotropic Materials: Including Strain-Softening Effects in Dynamic Problems [PDF]

open access: yes, 2013
Damage models are developed within the continuum damage mechanics framework which allows the description of material degeneration with general constitutive equations.
Gemkow, Karla Simone
core  

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