Results 21 to 30 of about 172,653 (302)

Recruitment of Oct4 protein to UV-damaged chromatin in embryonic stem cells. [PDF]

, 2011
BACKGROUND: Oct4 is a specific marker of embryonic stem cell (ESC) pluripotency. However, little is known regarding how Oct4 responds to DNA damage. Here, we investigated whether Oct4 recognizes damaged chromatin in mouse ESCs stably expressing GFP-Oct4.
Kozubek, Stanislav, Foltankova, Veronika, Stanislav Kozubek, Gabriela Šustáčková, Lenka Stixová, Stixová Lenka, Soňa Legartová, Bartova, Eva, Veronika Foltánková, Kozubek Stanislav, Bártová Eva, Legartová Soňa, Foltánková Veronika, Stixova, Lenka, Legartova, Sona, Eva Bártová, Sustackova, Gabriela, Šustáčková Gabriela   +17 more
core   +1 more source

Ensuring the Stability of the Genome: DNA Damage Checkpoints [PDF]

The Scientific World JOURNAL, 2001
The cellular response to DNA damage is vital for the cell s ability to maintain genomic integrity. Checkpoint signalling pathways, which induce a cell cycle arrest in response to DNA damage, are an essential component of this process. This is reflected by the functional conservation of these pathways in all eukaryotes from yeast to mammalian cells ...
Christine Latif, Susan H. Harvey, Susan J. O'Connell   +2 more
openaire   +3 more sources

Application of Buoyancy Support System to Secure Residual Buoyancy of Damaged Ships

Journal of Marine Science and Engineering, 2023
SOLAS (Safety of Life at Sea), which was first enacted in 1914 as a result of the Titanic disaster, presents mandatory requirements for ship safety, such as the adoption of watertight bulkheads.
Gyeong Joong Lee, Jang-Pyo Hong, Kwang Keun Lee, Hee Jin Kang   +3 more
doaj   +1 more source

Mitochondrial damage checkpoint in apoptosis and genome stability [PDF]

FEMS Yeast Research, 2004
Mitochondria perform multiple cellular functions including energy production, cell proliferation and apoptosis. Studies described in this paper suggest a role for mitochondria in maintaining genomic stability. Genomic stability appears to be dependent on mitochondrial functions involved in maintenance of proper intracellular redox status, ATP-dependent
openaire   +2 more sources

Advanced damage stability assessment for surface combatants [PDF]

Ocean Engineering, 2016
One of the major contributors to survivability of a surface combatant is her vulnerability to weapon effects and as such the damage stability characteristics have a direct influence on vulnerability. There are serious concerns about the limitations of the current semi-empirical deterministic criteria in which a combatant’s damage stability is assessed ...
Evangelos Boulougouris, Stuart Winnie, Apostolos Papanikolaou   +2 more
openaire   +5 more sources

Analysis of Local Damages Effect on Mechanical Responses of Underwater Shield Tunnel via Field Testing and Numerical Simulation

Applied Sciences, 2020
The investigation of concrete structural performance is crucial to maintain the stability of infrastructure. In order to assess structural stability, this work focuses on the development of an integrated framework to detect damaged conditions in the ...
Xuyan Tan, Weizhong Chen, Luyu Wang, Jianping Yang   +3 more
doaj   +1 more source

Regulation of MDM2 Stability After DNA Damage [PDF]

Journal of Cellular Physiology, 2015
Cells in our body are constantly exposed to various stresses and threats to their genomic integrity. The tumor suppressor protein p53 plays a critical role in successful defense against these threats by inducing apoptotic cell death or cell cycle arrest.
Jiaqi, Li, Manabu, Kurokawa
openaire   +2 more sources

A Review of Methods for Modelling Flooding, Its Progression and Outcome in Damaged Ships

Journal of Marine Science and Engineering
The timely and precise prediction of flooding progression and its eventual outcome in ships with breached hulls can lead to dramatic improvements in maritime safety through improved guidance for both emergency response and ship design.
José Miguel Rodrigues
doaj   +1 more source

A Numerical Method on Large Roll Motion in Beam Seas Under Intact and Damaged Conditions

Journal of Marine Science and Engineering
The second-generation intact stability criteria, including five stability failure modes, were approved by the International Maritime Organization (IMO) in 2020, and it is an urgent task to develop the numerical method for the significant roll motion ...
Jiang Lu, Yanjie Zhao, Chao Shi, Taijun Yu, Min Gu   +4 more
doaj   +1 more source

Global wave loads on a damaged ship

, 2012
A computational tool was applied based on a two dimensional linear method to predict the hydrodynamic loads for damaged ships. Experimental tests on a ship model have also been carried out to predict the hydrodynamic loads in various design conditions ...
Chan, Hoi-Sang, Dow, Robert S., Incecik, Atilla, Lee, Yongwon, Yongwon Lee, Hoi-Sang Chan, Yongchang Pu, Atilla Incecik, Pu, Yongchang, Robert S. Dow   +9 more
core   +1 more source