Results 101 to 110 of about 1,086,899 (293)
BuildingsA touch-off explosion on concrete slabs is considered one of the simplest yet most destructive forms of adversarial loading on building elements. It causes far greater damage than explosions occurring at a distance.
S. M. Anas +3 more
doaj +1 more source
Modelling bark beetle disturbances in a large scale forest scenario model to assess climate change impacts and evaluate adaptive management strategies [PDF]
To study potential consequences of climate-induced changes in the biotic disturbance regime at regional to national scale we integrated a model of Ips typographus (L. Scol. Col.) damages into the large-scale forest scenario model EFISCEN.
Lexer, M.J. +3 more
core +3 more sources
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Natural Disasters, Relief Aid, and Household Vulnerability in Pakistan: Evidence from a Pilot Survey in Khyber Pakhtunkhwa [PDF]
Based on a pilot survey, we analyze the damages caused by floods in Pakistan, 2010, the istribution of aid, and the extent of recovery at he household level.
Khan, Humayun +3 more
core
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Contract enforcement, litigation, and economic development [PDF]
, 2010 This paper introduces a model of litigation in a growth framework. Investors use litigation to enforce their financial contracts with entrepreneurs. A contest ensues in which both agents hire lawyers to increase their probability of winning the trial ...
Massenot, Baptiste
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
LA EJECUCIÓN DE ACTOS DAÑOSOS COMO FUNDAMENTO DE EXTINCIÓN DEL CONTRATO DE TRABAJO
Revista de Derecho (Coquimbo)El Código del Trabajo chileno establece como causa de extinción del contrato la realización por parte del trabajador de actos que provoquen perjuicio al empleador. Tradicionalmente, esta causa de despido se ha vinculado con los actos de sabotaje.
PEDRO IRURETA URIARTE
doaj +1 more source
Of Punitive Damages, Tax Deductions, and Tax-Aware Juries: A Response to Polsky and Markel [PDF]
, 2010 In “Taxing Punitive Damages,” Gregg D. Polsky and Dan Markel argue that defendants paying punitive damages are under-punished relative to juries’ intentions, because tax-unaware juries do not take into account the fact that the deductibility of punitive ...
Zelenak, Lawrence A.
core +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source