Results 111 to 120 of about 1,099,010 (309)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
LA EJECUCIÓN DE ACTOS DAÑOSOS COMO FUNDAMENTO DE EXTINCIÓN DEL CONTRATO DE TRABAJO
Revista de Derecho (Coquimbo)El Código del Trabajo chileno establece como causa de extinción del contrato la realización por parte del trabajador de actos que provoquen perjuicio al empleador. Tradicionalmente, esta causa de despido se ha vinculado con los actos de sabotaje.
PEDRO IRURETA URIARTE
doaj +1 more source
Numerical analysis of reinforced concrete shear keys in immersion joints
, 2017 Immersion joints are susceptible to be damaged first under various loadings due ito their smaller stiffhess compared to the adjacent tunnel elements. The induced Ideformations and the forces in the joint are transferred by shear keys.
Taerwe, Luc, Xiao, Wenhao, Yuan, Yong
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Gone with the Wind: JP and the Right to Clean Air Under EU Law
European Papers(Series Information) European Papers - A Journal on Law and Integration, 2024 9(1), 337-366 | Article | (Table of Contents) I. Introduction. - II. Air quality and EU law. - III. The CJEU’s case law on AQD. - iii.1. Public enforcement. - iii.2.
Luca Calzolari
doaj +1 more source
The Blockbuster Punitive Damages Awards [PDF]
This paper provides an analysis of 64 punitive damages awards of at least $100 million. Based on an inventory of these cases, there is evidence that these blockbuster awards are highly concentrated geographically, as two states account for 27 of the 64 ...
Viscusi, W. Kip
core +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source