Results 81 to 90 of about 342,051 (315)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

On the consideration of potential harm in the award of punitive damages [PDF]

open access: yes
Multiple empirical studies find that juries/courts take account of potential harm in the determination of punitive damages. The received view in economic theory, however, is that punitive damages should not depend on potential harm.
Jeffrey Wagner, Bharat Bhole
core  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Contract Damages and Investment Dynamics [PDF]

open access: yes
The present article provides an economic analysis to examine how contract damages affects both breach and investment decisions over time. Unlike the standard static model, this article studies a model in which, upon signing a contract, a seller invests ...
Tai-Yeong Chung, Alan Chan
core  

Long-term plasma exposure of ITER-like W/Cu monoblocks with pre-damaged surfaces in EAST experiments

open access: yesNuclear Fusion
In the ITER and future fusion devices, W/Cu monoblocks will be used as divertor target which are exposed to both steady state heat load and transient heat flux.
Zongxiao Guo   +12 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Damages under the CISG - selected problems

open access: yes, 2014
This paper addresses different contentious issues arising in the context of the right to damages under the CISG. The paper will therefore start with a brief description of the CISG, Art. 74 CISG et seq. as the basic provision on damages in the Convention
Buschtoens, Corinna
core  

Transposition of the antitrust damages directive : critical observations [PDF]

open access: yes, 2019
This article concerns the developing area of private enforcement of EU competition law, providing an analysis of the transposition across a broad selection of Member States (“MS”) of a major EU Directive introduced with the aim of harmonizing and ...
Marcos, Francisco   +2 more
core  

Death, happiness and the calculation of compensatory damages [PDF]

open access: yes, 2007
This paper studies the mental distress caused by bereavement. The largest emotional losses are from the death of a spouse; the second-worst in severity are the losses from the death of a child; the third-worst is the death of a parent.
Powdthavee, N.   +6 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

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