Results 71 to 80 of about 342,051 (315)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The Changing Landscape of Blockbuster Punitive Damages Awards [PDF]
This article investigates the determinants of the blockbuster punitive damages awards of at least $100 million. As of the end of 2008, there had been 100 such awards with an average value of $3.0 billion. The U.S.
Alison F. Del Rossi, W. Kip Viscusi
core
A função punitiva na indenização, demandas repetitivas e punitive damages [PDF]
, 2015 TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Jurídicas. Direito.Pretende-se neste projeto construir uma abordagem crítica quanto à aplicação da indenização punitiva, verificando a relação desta com questões relevantes na ...
Feltrin, Atílio Idalino Neto
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Punitive Damages and the Processing of Tort Claims [PDF]
Punitive damages are one of the most controversial aspects of tort litigation and have been the subject of various theoretical, empirical, and experimental studies. One criticism of punitive damages refers to the effect that they have on civil litigation
Susette M. Talarico +2 more
core
SOME ASPECTS OF HYDROLOGICAL RISK MANIFESTATION IN JIJIA BASIN [PDF]
Aerul şi Apa: Componente ale Mediului, 2012 Jijia river basin surface geographically fits in Moldavian Plateau, Plain of Moldavia subunit. Being lowered by 200 to 300 m compared to adjacent subunits, it appears as a depression with altitudes between 270-300 m.Through its position in the extra ...
D. BURUIANĂ +3 more
doaj
Technical Note: Alterations in the stone masonry of the Capitol Room of Sevilla City Hall
Materiales de Construccion, 2006 The main aim of this work has been to determine the causes of stone loss (small particles and one larger piece) and mortar loss in the coffered vault of the Capitol Room in the City Hall of Seville.
A. Barrios Padura +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2014 LPPs are Local Programs Procedures. These documents are used for the rapid deployment of new procedures and policies between updates of Local Assistance manuals, guidelines and programs.
Liquidated Damages, Terry L. Abbott
core
Analysis of the Railway Accident-Related Damages in South Korea
Applied Sciences, 2020 Railway accidents are critical issues characterized by a large number of injuries and fatalities per accident due to massive public transport systems. This study proposes a new approach for evaluating the damages resulting from railway accidents using ...
Man Sik Park +3 more
doaj +1 more source