Results 31 to 40 of about 85,838 (313)
Direct Quantitative Monitoring of Homology-Directed DNA Repair of Damaged Telomeres [PDF]
, 2018 Homology-directed DNA repair (HDR) is an evolutionary conserved mechanism that is required for genome integrity and organismal fitness across species. While a myriad of different factors and mechanisms are able to execute HDR, all forms necessitate common steps of DNA damage recognition, homology search and capture, and assembly of a DNA polymerase ...
Priyanka, Verma +3 more
openaire +2 more sources
The Type of Liability in Private Enforcement in Selected CEE Countries Relating to the Implementation of the Damages Directive [PDF]
Yearbook of Antitrust and Regulatory Studies, 2017 The article is devoted to the type of liability in selected CEE countries, namely those covered by the national reports drafted for the 2nd International Conference on Harmonization of Private Antitrust Enforcement: Central and Eastern European ...
Dominik Wolski
doaj +1 more source
TOWARD A EUROPEAN DIRECTIVE ON DAMAGES ACTIONS [PDF]
Journal of Competition Law and Economics, 2013 This paper critically reviews the European Commission’s proposed Directive on future rules concerning actions for damages for competition law infringements under national law. It is argued that the proposal underestimates the importance of loss of profits induced by increased prices and does little in ensuring that such effects will receive an equal ...
openaire +1 more source
Effect of National Decisions on Actions for Competition Damages in the CEE Countries [PDF]
Yearbook of Antitrust and Regulatory Studies, 2017 One of the main objectives of the so-called Damages Directive (2014/104/EU) was to make antitrust enforcement more effective. Although in most EU countries private antitrust enforcement has been possible subject to general rules of ...
Evelin Pärn-Lee
doaj +1 more source
DNA damage, homology-directed repair and DNA methylation
PLoS Genetics, 2005 To explore the link between DNA damage and gene silencing, we induced a DNA double-strand break in the genome of Hela or mouse embryonic stem (ES) cells using I-SceI restriction endonuclease. The I-SceI site lies within one copy of two inactivated tandem repeated green fluorescent protein (GFP) genes (DR-GFP).
Cuozzo C +13 more
openaire +8 more sources
Modelling the benefits of flood emergency management measures in reducing damages: a case study on Sondrio, Italy [PDF]
Natural Hazards and Earth System Sciences, 2013 The European "Floods Directive" 2007/60/EU has produced an important shift from a traditional approach to flood risk management centred only on hazard analysis and forecast to a newer one which encompasses other aspects relevant to decision-making and ...
D. Molinari, F. Ballio, S. Menoni
doaj +1 more source
Hydrogen Sulfide Induces Direct Radical-Associated DNA Damage
Molecular Cancer Research, 2007 Abstract Hydrogen sulfide (H2S) is produced by indigenous sulfate-reducing bacteria in the large intestine and represents an environmental insult to the colonic epithelium. Clinical studies have linked the presence of either sulfate-reducing bacteria or H2S in the colon with chronic disorders such as ulcerative colitis and colorectal ...
Matias S, Attene-Ramos +3 more
openaire +2 more sources
Direct Detection and Sequencing of Damaged DNA Bases [PDF]
Genome Integrity, 2011 Products of various forms of DNA damage have been implicated in a variety of important biological processes, such as aging, neurodegenerative diseases, and cancer. Therefore, there exists great interest to develop methods for interrogating damaged DNA in the context of sequencing.
Clark, Tyson A +3 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Osteonecrosis (ON) is a debilitating complication of acute lymphoblastic leukemia (ALL) therapy. While numerous studies have explored its incidence and associated risk factors, investigations using large‐scale cohorts remain important to characterize ON across heterogeneous populations.
Noémie de Villiers +5 more
wiley +1 more source