Results 111 to 120 of about 361,673 (283)

Spatiotemporally Ultrasound‐Controlled Nanoparticles Reprogramming Immunostimulatory Antigen‐Presenting Cancer‐Associated Fibroblasts to Enhance Cancer Immunotherapy

Advanced Science, EarlyView.
We developed an ultrasound‐controlled biomimetic nanoplatform, mRNA/V@M NPs, to co‐deliver CD74 mRNA and V‐9302 for fibrotic TNBC therapy. CD74 mRNA reprograms myCAFs into antigen‐presenting apCAF cells through the CD74‐MHC II pathway, while V‐9302 induces ICD and activates MHC I‐CD8+ T cell immunity.
Chen Ai, Weikai Sun, Yuxuan Zhao, Daqian Sun, Ting Meng, Yafei Qi, Fengyang Jiang, Jintang Sun, Zhiliang Gao, Dexin Yu   +9 more
wiley   +1 more source

Dynamic characteristics of negative stiffness structure with high static and low dynamic stiffness

Frontiers in Mechanical Engineering
Negative stiffness (NS) structures have obvious advantages in attenuating low-frequency vibration. Although most existing NS structures exhibit good damping effects, their stability is poor, limiting their application in complex mechanical systems.
Yuanshao Wang, Yuanshao Wang, Bao Zhang, Bao Zhang, Xiaoping Su   +4 more
doaj   +1 more source

Regulating Droplet Dynamics via Wormlike Micelle Networks: From Splash Suppression to Precise Confined Spreading

Advanced Science, EarlyView.
As displayed in Graphical Abstract image.tif, a molecular‐design strategy precisely tailors high‐speed droplet dynamics through programmed surfactant co‐assembly. The structural transition into an entangled wormlike micelle network completely suppresses stochastic splashing on fibrous substrates.
Shuling Liu, Beibei Xie, Xingyue Lou, Yu Deng, Lei Wang, Jiawei Li, Dongming Qi   +6 more
wiley   +1 more source

Investigation of the damping properties of 3D-printed liners with controlled perforation

Сучасний стан наукових досліджень та технологій в промисловості
This study focuses on thermoplastic polyurethane (TPU) liners with controlled internal perforation intended for use in the “residual limb–liner–socket” system of lower-limb prostheses.
Ігор Невлюдов, Олена Рубан, Дмитро Нікітін, Богдан Місан, Олександр Іохов   +4 more
doaj   +3 more sources

Experimental and finite element analysis of a two wheeler handlebar subjected to semi active constrained layer damping treatment

Scientific Reports
The study investigates the transient vibration analysis of two-wheeler handlebar and the optimization of vibration damping using constrained layer Magnetorheological Elastomers (MRE).
Keerthan Krishna, G. T. Mahesha, Sriharsha Hegde, Satish Shenoy Baloor   +3 more
doaj   +1 more source

Vibration Suppression Analysis of Spatial Pipelines with Viscoelastic Damping Layer Based on the Topology Optimization

Applied Sciences
Under the premise of a certain damping layer volume, topological optimization design of its attach shape can enable a pipeline system to achieve optimal damping performance.
Dongxu Du, Hongwei Ma, Wei Sun
doaj   +1 more source

Study on Air Spring System Damping Test

机车电传动, 2020
In order to explore the accuracy and maneuverability of air spring damping test, the damping experiments theory of free vibration, foundation excitation and half power bandwidth were described, then the air spring damping was studied experimentally and ...
Yaokun LONG, Te YE, Haitao CHENG, Tao HUANG   +3 more
doaj  

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Study of the Isolation Effect of a New Damping Material for Environmental Vibrations Due to High-Speed Train Operation

Advances in Civil Engineering
In order to effectively reduce the environmental vibration hazards of high-speed railways, a new viscous damping material for vibration isolation is proposed in this paper.
Xiangqiu Wang, Xuguang Liu, Guoping Lei, Huojun Zhang   +3 more
doaj   +1 more source

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source