Stanozolol and Danazol Have Different Effects on Hematopoiesis in the Murine Model of Immune-Mediated Bone Marrow Failure [PDF]
Frontiers in Medicine, 2021 Background: Stanozolol and danazol are widely used in the treatment of aplastic anemia; however, their mechanisms of action are unclear.Methods: Bone marrow mononuclear cells from 10 patients newly diagnosed with aplastic anemia and 10 healthy volunteers
Hongmin Li +3 more
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Delphi Consensus on Attenuated Androgen Use for Long‐Term Prophylaxis in Hereditary Angioedema: AURA Project [PDF]
Clinical and Translational AllergyBackground Danazol and other attenuated androgens (AAs) have been a cornerstone of Hereditary Angioedema (HAE) long‐term prophylaxis (LTP) for decades, alongside intravenous plasma‐derived C1INH (pdC1INH). Danazol's potential androgenic effects, however,
Eunice Dias de Castro +3 more
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Assessment of potential drug-drug interactions in patients with hereditary angioedema from the ITACA cohort: simulations from a real-life dataset considering danazol versus berotralstat [PDF]
Frontiers in PharmacologyBackgroundDanazol is regularly used as a prophylactic treatment in patients with Hereditary angioedema due to C1-inhibitor deficiency (HAE-C1INH). However, this drug is characterized by a risk of drug-drug interactions (DDIs).
Andrea Zanichelli +26 more
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Rapid early remission in a patient with severe aplastic anemia: a case report of hetrombopag, cyclosporine, and danazol combination therapy [PDF]
Frontiers in ImmunologySevere aplastic anemia (SAA) is a life-threatening bone marrow failure syndrome that is caused primarily by immune-mediated destruction of hematopoietic stem cells.
Yuting Dai +3 more
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Therapeutic potential of luteolin in central precocious puberty: insights from a danazol-induced rat model [PDF]
Frontiers in EndocrinologyBackgroundRecently, central precocious puberty (CPP) is becoming a major public health concern worldwide due to its enhanced prevalence. Traditional Chinese medicine (TCM) compounds offer unique therapeutic advantages for treating this condition, and ...
Zhijian Zha +14 more
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Application of different methods to predict the lipophilicity parameter of danazol [PDF]
Farmacja Polska, 2021 The aim of this study was to evaluate the applicability of both methods, i.e. reversed-phase thin-layer chromatography (RP-TLC) and high-performance thin-layer chromatography (RP-HPTLC), and computational algorithms to determine the lipophilicity ...
Małgorzata Dołowy, Rafał Sochacki
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No effect of danazol treatment in patients with advanced idiopathic pulmonary fibrosis
ERJ Open Research, 2023 Background Telomere dysfunction can underly the development of idiopathic pulmonary fibrosis (IPF), and recent work suggests that patients with telomere syndromes might benefit from treatment with androgens, such as danazol.
Thijs W. Hoffman +4 more
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Pharmaceuticals, 2022 Danazol is a treatment option for autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Three patients with AIHA and eight patients with ITP between 2008 and 2022 were enrolled in the Rheumatology Outpatient Clinic of Chang Gung Memorial ...
Hsu-En Huang +8 more
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Plants, 2021 Anemarrhenae rhizome and Phellodendri cortex have historically been used for the treatment of precocious puberty (PP) in oriental medicine. Our study aimed to evaluate the effect of APE, a mixture of the extracts from these herbs, against danazol-induced
Kyeong Ri Kim +9 more
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