Results 201 to 210 of about 9,385 (245)

Successful sedation with remimazolam and alfentanil in a child susceptible to malignant hyperthermia: a case report. [PDF]

BMC Anesthesiol
Zhu K, Wu S, Hao X, Wang C.
europepmc   +1 more source

The novel rapid formulation of intravenous dantrolene (NPJ5008) versus standard dantrolene (Dantrium®): A clinical part-randomised phase 1 study in healthy volunteers. [PDF]

Eur J Anaesthesiol
Ng Kwet Shing RH, Clayton LB, Smith SL, Watson MJ, McKenzie LM, Chalmers DP, Whitaker G, Bilmen JG.   +7 more
europepmc   +1 more source

Malignant hyperthermia during orthognathic surgery: a case report. [PDF]

Hua Xi Kou Qiang Yi Xue Za Zhi
Li Y, Lin J, Luo W, Luo K, Luo L.
europepmc   +1 more source

Distinct calcium sources regulate temporal profiles of NMDAR and mGluR-mediated protein synthesis. [PDF]

Life Sci Alliance
Ramakrishna S, Radhakrishna BK, Kaladiyil AP, Shah NM, Basavaraju N, Freude KK, Kommaddi RP, Muddashetty RS.   +7 more
europepmc   +1 more source

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Ryanodine receptor inhibition with acute dantrolene treatment reduces arrhythmia susceptibility in human hearts.

American Journal of Physiology. Heart and Circulatory Physiology, 2023
Ryanodine receptor 2 (RyR2) hyperactivity is observed in structural heart diseases that are a result of ischemia or heart failure. It causes abnormal calcium handling and calcium leaks that cause metabolic, electrical, and mechanical dysfunction, which ...
Sharon A. George, Jaclyn Brennan-McLean, Katy A Trampel, E. Rytkin, N. R. Faye, B. Knollmann, Igor R. Efimov   +6 more
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Effects of chronic intranasal dantrolene on nasal mucosa morphology in mice.

European Review for Medical and Pharmacological Sciences, 2022
OBJECTIVE We have previously shown that the intranasal administration of dantrolene ameliorated cognitive dysfunction in the 5XFAD mouse model of Alzheimer's disease.
B. Jiang, Y. Shi, M. B. Abou, L. Xu, G. Liang, H. Wei   +5 more
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Stabilizing Cardiac Ryanodine Receptor With Dantrolene Treatment Prevents Binge Alcohol–Enhanced Atrial Fibrillation in Rats

Journal of Cardiovascular Pharmacology, 2022
: Binge drinking is a risk factor for cardiac arrhythmias, known as the holiday heart syndrome. Atrial fibrillation (AF) is the most frequently diagnosed arrhythmia in this condition.
Lisa V. Greco, A. Migirov, K. Ojamaa, Ying Li, Yuan Huang, Satoru Kobayashi, Lars Udo-Bellner, Randy F. Stout, T. Cohen, Youhua Zhang   +9 more
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Dantrolene repurposed to treat sepsis or septic shock and COVID-19 patients.

European Review for Medical and Pharmacological Sciences, 2021
OBJECTIVE Disruption of intracellular Ca2+ homeostasis via excessive and pathological Ca2+ release from the endoplasmic reticulum (ER) and/or sarcoplasmic reticulum (SR) through ryanodine receptor (RyRs) Ca2+ channels play a critical role in the ...
H. Wei, G. Liang, R. Vera
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Hexamorphism of Dantrolene: Insight into the Crystal Structures, Stability, and Phase Transformations

, 2021
Dantrolene represents yet another interesting example of abundant molecular crystal polymorphism existing in at least six different neat polymorphs, three of which can be obtained via crystallizati...
Artis Kons, A. Mishnev, T. A. Mukhametzyanov, Alexey V. Buzyurov, S. Lapuk, A. Be̅rziṇš   +5 more
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DANTROLENE INDUCES MITIGATION OF MYOCARDIAL ISCHEMIA-REPERFUSION INJURY BY RYANODINE RECEPTOR INHIBITION.

Seminars in Thoracic and Cardiovascular Surgery, 2021
The impairment of intracellular calcium homeostasis plays an essential role during ischemia-reperfusion injury. Calcium release from sarcoplasmic reticulum which is triggered by myocardial ischemia is mainly mediated by ryanodine receptors.
I. Samiotis, N. Papakonstantinou, P. Dedeilias, I. Vasileiadis, A. Papalois, S. Deftereos, A. Kotanidou   +6 more
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