Results 181 to 190 of about 4,970 (234)

In vitroantioxidant properties of dantrolene sodium

Pharmacological Research, 2001
Dantrolene sodium is a skeletal muscle relaxant, which inhibits intracellular Ca2+ release from the sarcoplasmic reticulum. The aim of this study is to examine possible in vitro antioxidant effects of dantrolene sodium. For this reason, the in vitro antioxidant effects of dantrolene sodium were studied using thiocyanate methods.
BUYUKOKUROGLU, Mehmet Emin, OKTAY, Münir, KUFREVIOGLU, Ömer İrfan, Gulcin, I   +3 more
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Dantrolene sodium: Effects of smooth muscle

European Journal of Pharmacology, 1978
The effects of dantrolene sodium on smooth muscle were evaluated in vitro using the guinea pig ileum and the guinea pig vas deferens preparations. Dantrolene irreversibly decreased the strength of the responses of the ileum to acetylcholine, histamine, potassium chloride and electrical stimulation.
S, Graves, K L, Dretchen, G O, Kruger
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Dantrolene sodium: Effects on isolated cardiac tissues

Journal of Molecular and Cellular Cardiology, 1983
The effects of dantrolene sodium on dog Purkinje fibers, cat atrial and ventricular muscles were studied. Action potential duration was significantly increased and contractility was significantly decreased by dantrolene in all three types of tissue.
J J, Salata, J A, Wasserstrom, J, Jalife
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Dantrolene sodium (dantrium)

Drug and Therapeutics Bulletin, 1976
Dantrolene sodium (Dantrium - Eaton) has been advertised as a muscle relaxant for patients with spasticity, with claims that it is ‘the only direct-acting antispastic agent’.
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Pharmacokinetics of dantrolene sodium in horses

Journal of Veterinary Pharmacology and Therapeutics, 1987
The pharmacokinetics of dantrolene sodium were investigated in horses following both intravenous (2 mg/kg) and intragastric (4 mg/kg) administration. Two ponies also received dantrolene sodium intravenously (2 mg/kg) in a pilot study to obtain preliminary kinetic data and to determine urinary and biliary excretion of the intact drug.
M H, Court, L R, Engelking, N H, Dodman, M S, Anwer, D C, Seeler, M, Clark   +5 more
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Dantrolene Sodium: Effects on Crustacean Muscle

Canadian Journal of Physiology and Pharmacology, 1974
The effect of dantrolene sodium, a muscle relaxant effective on vertebrate skeletal muscle, has been studied on the stretcher muscle of a crab (Callinectes sapidus). The drug rapidly and reversibly attenuates the muscle contractile response to direct and indirect stimulation.
L L, Odette, H L, Atwood
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Dantrolene sodium and hepatic injury

Neurology, 1990
This is a report on hepatic adverse events associated with dantrolene therapy. All cases reported to the manufacturer are included, from all sources, through 1987. Of 122 cases containing sufficient data to analyze, 47 patients had asymptomatic transaminase elevations, 12 had additional mild (less than or equal to 2.5 mg/dl) hyperbilirubinemia, 36 had ...
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Effect of Dantrolene Sodium in Myotonic Dystrophy

European Neurology, 1983
The effect of dantrolene sodium, using a dosage of 120 mg/day, was investigated in 3 patients suffering from myotonic dystrophy. These patients showed a marked reversible deterioration of the clinical symptoms, caused by a reduction of the isometric strength.
B, Mamoli, P, Dal-Bianco, K, Zeitlhofer
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The mechanism of action of dantrolene sodium.

The Journal of Pharmacology and Experimental Therapeutics, 1977
Dantrolene sodium is thought to affect some step in the excitation-contraction coupling process. Using a point voltage clamp to determine mechanical thresholds of individual fibers of frog, rat and goat skeletal muscle preparations, we found that dantrolene both raises (moves to more positive potentials) the rheobasic potential and increases the ...
K G, Morgan, S H, Bryant
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