Results 51 to 60 of about 4,965 (233)

Pharmacotherapy of Spasticity in Children With Cerebral Palsy

Journal of the Formosan Medical Association, 2011
Spasticity is a common disability in children with cerebral palsy. Pharmacological and non-pharmacological treatments, including physical therapy, occupational therapy, orthotics, rhizotomy, and orthopedic surgery, all play important roles in the ...
Chia-Ying Chung, Chia-Ling Chen, Alice May-Kuen Wong   +2 more
doaj   +1 more source

Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits [PDF]

, 2018
Hypertrophic cardiomyopathy (HCM) is a primary disorder of contractility in heart muscle. To gain mechanistic insight and guide pharmacological rescue, this study models HCM using isogenic pairs of human induced pluripotent stem cell-derived ...
Barriales-Villa, Roberto, Bhagwan, Jamie R., Denning, Chris, Eschenhagen, Thomas, Hansen, Arne, Harding, Sian E., Mannhardt, Ingra, Marston, Steve, Monserrat, Lorenzo, Mosqueira, Diogo, Owen, Thomas, Patel, Asha, Scott, Elizabeth, Smith, James G.w.   +13 more
core   +2 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper [PDF]

, 2016
BACKGROUND AND OBJECTIVES: Treatment of spasticity poses a major challenge given the complex clinical presentation and variable efficacy and safety profiles of available drugs. We present a systematic review of the pharmacological treatment of spasticity
Comi, G, Gold, R, Hartung, HP, Montalban, X, Otero-Romero, S, Sastre-Garriga, J, Soelberg Sørensen, P, Thompson, AJ, Vermersch, P   +8 more
core   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source

Ryanodine receptors: physiological function and deregulation in Alzheimer disease [PDF]

, 2014
BackgroundHealth-care professionals have a responsibility to be attentive to patients’ adherence behavior but it could be difficult to identify poor adherence in the context of clinical practice.
Axelsson, Malin, Ekerljung, Linda, Lundbäck, Bo, Lötvall, Jan   +3 more
core   +2 more sources

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

Advanced Science, EarlyView.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang, Zihan Li, Lei Wang, Haitao Zhang, Xiaoshan Yang, Lili Bao, Geng Dou, Lili Ren, Yajing Fu, Lan Li, Shengkai Gong, Yang Zhou, Feng Ding, Lu Yu, Haotian Luo, Yao Liu, Fuyang Zhang, Hui Yu, Siying Liu, Xueming Liu, Fulan Wei, Shiyu Liu   +21 more
wiley   +1 more source

Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle [PDF]

, 2003
SummaryDNA methylation is a covalent biochemical modification controlling chromatin structure and gene expression. Exercise elicits gene expression changes that trigger structural and metabolic adaptations in skeletal muscle.
Barrès, Romain, Yan, Jie, Egan, Brendan, Treebak, Jonas Thue, Rasmussen, Morten, Fritz, Tomas, Caidahl, Kenneth, Krook, Anna, O'Gorman, Donal J., Zierath, Juleen R.   +9 more
core   +1 more source

Real‐Time Force Monitoring of Electrically Stimulated 3D‐Bioengineered Muscle Bioactuators Using Organic Sensors with Tunable Sensitivity

Advanced Intelligent Systems, EarlyView.
The integration of sensing elements in bioengineered actuators is key to obtain real‐time information about their performance and further control/automation. By coupling flexible organic field‐effect transistor to a skeletal muscle actuator we demonstrate the feasibility to record in real‐time its contractile behavior when stimulated by electrical ...
Stefano Lai, Judith Fuentes, Maria Guix, Giulia Casula, Piero Cosseddu, Samuel Sánchez   +5 more
wiley   +1 more source

Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts. [PDF]

, 2015
AIMS: Cardiac ryanodine receptor mutations are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), and some, including RyR2-P2328S, also predispose to atrial fibrillation.
Chandrasekharan, KH, Fraser, JA, Guzadhur, L, Huang, CL-H, Jafferji, DIG, King, JH, Matthews, HR, Salvage, SC   +7 more
core   +2 more sources