Results 61 to 70 of about 1,064,868 (260)
Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle [PDF]
, 2003 SummaryDNA methylation is a covalent biochemical modification controlling chromatin structure and gene expression. Exercise elicits gene expression changes that trigger structural and metabolic adaptations in skeletal muscle.
Barrès, Romain +9 more
core +1 more source
Advanced Science, Volume 13, Issue 3, 14 January 2026.Three food‐grade nanomaterials induce dysregulated RyR‐Ca2+ signaling through epigenetic modifications. This dysregulation impairs the autophagic clearance process, ultimately leading to abnormal Aβ deposition and increase phosphorylated tau levels.
Jiaxin Shang +7 more
wiley +1 more source
Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts. [PDF]
, 2015 AIMS: Cardiac ryanodine receptor mutations are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), and some, including RyR2-P2328S, also predispose to atrial fibrillation.
Chandrasekharan, KH +7 more
core +2 more sources
Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan +6 more
wiley +1 more source
Role of CA2+/calmodulin on ethanol neurobehavioral effects [PDF]
, 2014 Rationale. The cAMP-dependent protein kinase A (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol-induced behaviors.
Baliño, Pablo +2 more
core +1 more source
Clinical Case Reports, Volume 13, Issue 12, December 2025.MRI brain revealing features consistent with central diabetes insipidus (Figure A), pontine atrophy (Figure B), and bilateral optic nerve atrophy (Figure C) in a young, non‐autoimmune diabetic patient: imaging clue to Wolfram syndrome. ABSTRACT Wolfram syndrome is a rare autosomal recessive disorder characterized by diabetes insipidus, diabetes ...
Sushrut Ingawale +4 more
wiley +1 more source
Orphanet Journal of Rare Diseases, 2007 Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine ...
Pollock Neil +4 more
doaj +1 more source
The medical management of cerebral palsy [PDF]
, 2016 Medical management of cerebral palsy is a complex issue that should be undertaken with the overall aim to improve comfort, function in every day life, self confidence, participation and independence. Although the main focus is commonly the motor disorder,
Kurian, MA, Smith, M
core +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Ion channels
British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +86 more
wiley +1 more source
Electroacupuncture for Decorticate Rigidity of the Upper Limbs in a Patient with Anoxic Brain Damage
Case Reports in Medicine, 2013 Decorticate rigidity is a type of abnormal posturing that can make it difficult to move a patient and to change the patient’s position to prevent a decubitus ulcer. This condition poses a latent risk of bed sores.
WooSang Jung +6 more
doaj +1 more source