Results 61 to 70 of about 4,965 (233)
Clinical Pharmacology &Therapeutics, EarlyView.Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan +6 more
wiley +1 more source
Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes
The Journal of Physiology, EarlyView.Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve +11 more
wiley +1 more source
Role of CA2+/calmodulin on ethanol neurobehavioral effects [PDF]
, 2014 Rationale. The cAMP-dependent protein kinase A (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol-induced behaviors.
Baliño, Pablo +2 more
core +1 more source
Meeting the UN Sustainable Development Goals with Mechanochemistry
Angewandte Chemie, Volume 136, Issue 50, December 9, 2024.This minireview explores how mechanochemistry can address the United Nations Sustainable Development Goals. The potential of mechanochemistry to address climate change, energy scarcity, food insecurity and waste pollution by providing more efficient and environmentally friendly chemical processes is highlighted.
Jasna Alić +3 more
wiley +2 more sources
Orphanet Journal of Rare Diseases, 2007 Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine ...
Pollock Neil +4 more
doaj +1 more source
Food Science &Nutrition, Volume 13, Issue 9, September 2025.We conducted a comprehensive search of publicly available databases. The main focus is to investigate the pharmacological effects and mechanisms of Portulaca oleracea L. in the treatment of musculoskeletal disorders. This study aims to provide a reference for further research into the active components of this plant. ABSTRACT Portulaca oleracea L. is a
Yanxin Li +8 more
wiley +1 more source
Electroacupuncture for Decorticate Rigidity of the Upper Limbs in a Patient with Anoxic Brain Damage
Case Reports in Medicine, 2013 Decorticate rigidity is a type of abnormal posturing that can make it difficult to move a patient and to change the patient’s position to prevent a decubitus ulcer. This condition poses a latent risk of bed sores.
WooSang Jung +6 more
doaj +1 more source
The medical management of cerebral palsy [PDF]
, 2016 Medical management of cerebral palsy is a complex issue that should be undertaken with the overall aim to improve comfort, function in every day life, self confidence, participation and independence. Although the main focus is commonly the motor disorder,
Kurian, MA, Smith, M
core +1 more source
Pain Practice, Volume 25, Issue 7, September 2025.ABSTRACT Introduction Discogenic low back pain can be severely disabling, clinically challenging to diagnose, and expensive to treat. Disc degeneration is characterized by disc dehydration, which diminishes the ability of the disc to distribute pressure, making it more susceptible to damage, and leading to annular tears, fissures, and a higher ...
Wouter K. M. van Os +6 more
wiley +1 more source
Bile acids activate ryanodine receptors in pancreatic acinar cells via a direct allosteric mechanism [PDF]
, 2015 The earliest critical event of pancreatitis is a long lasting high amplitude rise of intracellular Ca(2+) concentration of the acinar cell, which can be triggered by high concentration of bile acids.
Almássy, János +4 more
core +1 more source